A0A8I5ZUG3 · A0A8I5ZUG3_RAT
- ProteinAdhesion G protein-coupled receptor A2
- GeneAdgra2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1252 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | plasma membrane | |
Cellular Component | Wnt signalosome | |
Molecular Function | G protein-coupled receptor activity | |
Biological Process | angiogenesis | |
Biological Process | canonical Wnt signaling pathway | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | central nervous system development | |
Biological Process | endothelial cell migration | |
Biological Process | negative regulation of vascular endothelial growth factor signaling pathway | |
Biological Process | positive regulation of canonical Wnt signaling pathway | |
Biological Process | positive regulation of endothelial cell migration | |
Biological Process | regulation of angiogenesis | |
Biological Process | regulation of chemotaxis | |
Biological Process | regulation of establishment of blood-brain barrier | |
Biological Process | sprouting angiogenesis |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZUG3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 811-832 | Helical | ||||
Sequence: VVYPCTALLLLCLFSTIITYIL | ||||||
Transmembrane | 844-864 | Helical | ||||
Sequence: WHMLLNLCFHMAMTSAVFVGG | ||||||
Transmembrane | 926-946 | Helical | ||||
Sequence: FYLIAGGIPLIICGITAAVNI | ||||||
Transmembrane | 966-989 | Helical | ||||
Sequence: AFYIPVALILPITWIYFLCAGLHL | ||||||
Transmembrane | 1031-1049 | Helical | ||||
Sequence: FLYLAMWACGALAVSQRWL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-47 | Disordered | ||||
Sequence: MAPRPALGRPGLPLSTPLARSGPSSRRTVRPLRCRSPRGDGLMGAGG | ||||||
Domain | 302-386 | Ig-like | ||||
Sequence: QGDRLPFQCSASYLGNDTQIHWYHNGAPMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQGNTSKKVEIV | ||||||
Domain | 369-463 | G-protein coupled receptors family 2 profile 1 | ||||
Sequence: ECSVSTVQGNTSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTN | ||||||
Domain | 808-983 | G-protein coupled receptors family 2 profile 2 | ||||
Sequence: LHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFVGGVTLTNYQMVCQAVGITLHYSSLSSLLWMGVKARVLHKELSWRAPPPEEGEAAPPGPRPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILPITWIYFL | ||||||
Region | 1064-1226 | Disordered | ||||
Sequence: VARGDGEPEPTGSRSSLAPRHHNNLHHGRRVHKSRAKGHRAGETGGKSRLKALRAGTSPGAPELLSSESGSLHNSPSDSYPGSSRNSPGDGLPLEGEPMLTPSEGSDTSAAQIPETGRPGQRRSASRDNLKGSGSALERESKRRSYPLNTTSLNGAPKGGKYE | ||||||
Compositional bias | 1083-1100 | Basic residues | ||||
Sequence: RHHNNLHHGRRVHKSRAK | ||||||
Compositional bias | 1125-1149 | Polar residues | ||||
Sequence: PELLSSESGSLHNSPSDSYPGSSRN |
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length1,252
- Mass (Da)135,012
- Last updated2022-05-25 v1
- ChecksumF36FE239824391D8
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D4ADC7 | D4ADC7_RAT | Adgra2 | 1378 | ||
A0A8I6GIV5 | A0A8I6GIV5_RAT | Adgra2 | 1313 | ||
A0A8I5ZMQ6 | A0A8I5ZMQ6_RAT | Adgra2 | 1122 | ||
A0A8I6G7Z0 | A0A8I6G7Z0_RAT | Adgra2 | 1343 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1083-1100 | Basic residues | ||||
Sequence: RHHNNLHHGRRVHKSRAK | ||||||
Compositional bias | 1125-1149 | Polar residues | ||||
Sequence: PELLSSESGSLHNSPSDSYPGSSRN |
Keywords
- Technical term