A0A8I5ZN16 · A0A8I5ZN16_RAT
- ProteinProtein kinase C
- GenePrkcg
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids646 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Note: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 186 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 187 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 193 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 195 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI) | |||
Binding site | 245 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI) | |||
Binding site | 246 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 247 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 248 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 251 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 252 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 254 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 329 | ATP (UniProtKB | ChEBI) | |||
Active site | 429 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | ATP binding | |
Molecular Function | diacylglycerol-dependent serine/threonine kinase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein phosphorylation | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein kinase C
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZN16
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 35-85 | Phorbol-ester/DAG-type | |||
Domain | 100-150 | Phorbol-ester/DAG-type | |||
Domain | 157-275 | C2 | |||
Domain | 250-563 | Protein kinase | |||
Domain | 564-634 | AGC-kinase C-terminal | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length646
- Mass (Da)72,963
- Last updated2022-05-25 v1
- MD5 ChecksumEAED0C3DB5673CC8A587229E04C95717
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P63319 | KPCG_RAT | Prkcg | 697 |
Keywords
- Technical term