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A0A8I5ZN16 · A0A8I5ZN16_RAT

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site186Ca2+ 1 (UniProtKB | ChEBI)
Binding site187Ca2+ 2 (UniProtKB | ChEBI)
Binding site193Ca2+ 2 (UniProtKB | ChEBI)
Binding site195a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site245a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site246Ca2+ 2 (UniProtKB | ChEBI)
Binding site247Ca2+ 2 (UniProtKB | ChEBI)
Binding site248Ca2+ 2 (UniProtKB | ChEBI)
Binding site251Ca2+ 3 (UniProtKB | ChEBI)
Binding site252Ca2+ 3 (UniProtKB | ChEBI)
Binding site254Ca2+ 1 (UniProtKB | ChEBI)
Binding site329ATP (UniProtKB | ChEBI)
Active site429Proton acceptor

GO annotations

AspectTerm
Cellular Componentdendrite
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular FunctionATP binding
Molecular Functiondiacylglycerol-dependent serine/threonine kinase activity
Molecular Functionzinc ion binding
Biological Processprotein phosphorylation
Biological Processrhythmic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein kinase C
  • EC number

Gene names

    • Name
      Prkcg

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I5ZN16

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cell projection, dendrite
Cytoplasm, perinuclear region
Synapse, synaptosome

Keywords

PTM/Processing

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-85Phorbol-ester/DAG-type
Domain100-150Phorbol-ester/DAG-type
Domain157-275C2
Domain250-563Protein kinase
Domain564-634AGC-kinase C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    646
  • Mass (Da)
    72,963
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    EAED0C3DB5673CC8A587229E04C95717
MAGLGPGGGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTSDEIHITVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTKTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYEVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIAPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
P63319KPCG_RATPrkcg697

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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