A0A8I5ZMX2 · A0A8I5ZMX2_RAT
- ProteinADAM metallopeptidase with thrombospondin type 1, motif 3
- GeneAdamts3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1203 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 259 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 259 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 351 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 398 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 399 | ||||
Binding site | 402 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 408 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 455 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 458 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 458 | Ca2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | extracellular space | |
Molecular Function | endopeptidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | peptidase activity | |
Biological Process | collagen biosynthetic process | |
Biological Process | extracellular matrix organization | |
Biological Process | in utero embryonic development | |
Biological Process | positive regulation of vascular endothelial growth factor signaling pathway | |
Biological Process | protein processing | |
Biological Process | vascular endothelial growth factor production |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZMX2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5035149949 | 23-1203 | |||
Disulfide bond | 333↔382 | ||||
Disulfide bond | 376↔455 | ||||
Disulfide bond | 415↔441 | ||||
Disulfide bond | 482↔507 | ||||
Disulfide bond | 493↔516 | ||||
Disulfide bond | 502↔535 | ||||
Disulfide bond | 529↔540 | ||||
Disulfide bond | 563↔600 | ||||
Disulfide bond | 567↔605 | ||||
Disulfide bond | 578↔590 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 112-139 | Disordered | |||
Domain | 256-460 | Peptidase M12B | |||
Domain | 1012-1055 | PLAC | |||
Region | 1127-1203 | Disordered | |||
Compositional bias | 1141-1157 | Polar residues | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,203
- Mass (Da)135,079
- Last updated2022-05-25 v1
- MD5 Checksum4336E6A26571E8B1CE40E88C3A167E48
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AA07 | A0A8I6AA07_RAT | Adamts3 | 1202 | ||
D4AD55 | D4AD55_RAT | Adamts3 | 910 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1141-1157 | Polar residues | |||
Keywords
- Technical term