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A0A8I5ZMX2 · A0A8I5ZMX2_RAT

  • Protein
    ADAM metallopeptidase with thrombospondin type 1, motif 3
  • Gene
    Adamts3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

112031002003004005006007008009001,0001,1001,200
Type
IDPosition(s)Description
Binding site259Ca2+ 2 (UniProtKB | ChEBI)
Binding site259Ca2+ 1 (UniProtKB | ChEBI)
Binding site351Ca2+ 1 (UniProtKB | ChEBI)
Binding site398Zn2+ (UniProtKB | ChEBI); catalytic
Active site399
Binding site402Zn2+ (UniProtKB | ChEBI); catalytic
Binding site408Zn2+ (UniProtKB | ChEBI); catalytic
Binding site455Ca2+ 1 (UniProtKB | ChEBI)
Binding site458Ca2+ 2 (UniProtKB | ChEBI)
Binding site458Ca2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular matrix
Cellular Componentextracellular space
Molecular Functionendopeptidase activity
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Molecular Functionpeptidase activity
Biological Processcollagen biosynthetic process
Biological Processextracellular matrix organization
Biological Processin utero embryonic development
Biological Processpositive regulation of vascular endothelial growth factor signaling pathway
Biological Processprotein processing
Biological Processvascular endothelial growth factor production

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase with thrombospondin type 1, motif 3

Gene names

    • Name
      Adamts3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I5ZMX2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_503514994923-1203
Disulfide bond333↔382
Disulfide bond376↔455
Disulfide bond415↔441
Disulfide bond482↔507
Disulfide bond493↔516
Disulfide bond502↔535
Disulfide bond529↔540
Disulfide bond563↔600
Disulfide bond567↔605
Disulfide bond578↔590

Keywords

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region112-139Disordered
Domain256-460Peptidase M12B
Domain1012-1055PLAC
Region1127-1203Disordered
Compositional bias1141-1157Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,203
  • Mass (Da)
    135,079
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    4336E6A26571E8B1CE40E88C3A167E48
MVFLSLWLIAASLVEVRTSADGQAGAEEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEQLFFNVTAFGRDFHLRLRPNTHFIAPGAVVEWHETAPRPGNTTDPRNSRPHRSSSEGGWRSEPLQTSCAYVGDIMDVPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMDEENGRIHIVYKRSAMERAPRDVSEDVYYKESNLEGLDDLGTVYSNIGQQLNETTRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKSDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRGAFVLPKGARNISLAETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQECTHPLWAAEAWEHCSRSCGSSGYQLRTVRCLQPLQDGTNRSVHSRYCLGERPESRRPCNRIPCPAQWKTGPWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYSELCCESCSKRSGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTPFLPYYSGSRADKKSLSSVSSVANPSAYAAFRSSSRASVSFPRKKAQEGGTKTPVSMPPSSSIKTDHLHSSSPGAAAPSPAITDSIGASPQTRTPKKDGKTISRRHPIRSTASER

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AA07A0A8I6AA07_RATAdamts31202
D4AD55D4AD55_RATAdamts3910

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1141-1157Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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