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A0A8I5ZMR6 · A0A8I5ZMR6_RAT

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site186Ca2+ 1 (UniProtKB | ChEBI)
Binding site187Ca2+ 2 (UniProtKB | ChEBI)
Binding site193Ca2+ 2 (UniProtKB | ChEBI)
Binding site195a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site245a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site246Ca2+ 2 (UniProtKB | ChEBI)
Binding site247Ca2+ 2 (UniProtKB | ChEBI)
Binding site248Ca2+ 2 (UniProtKB | ChEBI)
Binding site252Ca2+ 3 (UniProtKB | ChEBI)
Binding site254Ca2+ 1 (UniProtKB | ChEBI)
Binding site345-353ATP (UniProtKB | ChEBI)
Binding site368ATP (UniProtKB | ChEBI)
Active site463Proton acceptor

GO annotations

AspectTerm
Cellular Componentciliary basal body
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functioncalcium,diacylglycerol-dependent serine/threonine kinase activity
Molecular Functionenzyme binding
Molecular Functionhistone H3T6 kinase activity
Molecular Functionzinc ion binding
Biological Processdesmosome assembly
Biological Processnegative regulation of glial cell apoptotic process
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of angiotensin-activated signaling pathway
Biological Processpositive regulation of blood vessel endothelial cell migration
Biological Processpositive regulation of cell adhesion
Biological Processpositive regulation of endothelial cell proliferation
Biological Processpositive regulation of lipopolysaccharide-mediated signaling pathway
Biological Processpositive regulation of mitotic cell cycle
Biological Processpost-translational protein modification
Biological Processprotein phosphorylation
Biological Processregulation of platelet aggregation
Biological Processresponse to interleukin-1

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein kinase C
  • EC number

Gene names

    • Name
      Prkca

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I5ZMR6

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Mitochondrion membrane
; Peripheral membrane protein
Nucleus

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-86Phorbol-ester/DAG-type
Domain101-151Phorbol-ester/DAG-type
Domain158-275C2
Domain339-597Protein kinase
Domain598-684AGC-kinase C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    688
  • Mass (Da)
    78,766
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    B2AEF136B0E78C41B552723307B639A4
MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVNFCTKMHWLQWASRPSCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P05696KPCA_RATPrkca672
A0A8I6ABU2A0A8I6ABU2_RATPrkca667
A0A8I6G952A0A8I6G952_RATPrkca609
F1M2P8F1M2P8_RATPrkca636
F1LS98F1LS98_RATPrkca672

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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