A0A8I5ZMR6 · A0A8I5ZMR6_RAT
- ProteinProtein kinase C
- GenePrkca
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids688 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Note: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 186 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 187 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 193 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 195 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI) | |||
Binding site | 245 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI) | |||
Binding site | 246 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 247 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 248 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 252 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 254 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 345-353 | ATP (UniProtKB | ChEBI) | |||
Binding site | 368 | ATP (UniProtKB | ChEBI) | |||
Active site | 463 | Proton acceptor | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein kinase C
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZMR6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Mitochondrion membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 36-86 | Phorbol-ester/DAG-type | |||
Domain | 101-151 | Phorbol-ester/DAG-type | |||
Domain | 158-275 | C2 | |||
Domain | 339-597 | Protein kinase | |||
Domain | 598-684 | AGC-kinase C-terminal | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length688
- Mass (Da)78,766
- Last updated2022-05-25 v1
- MD5 ChecksumB2AEF136B0E78C41B552723307B639A4
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P05696 | KPCA_RAT | Prkca | 672 | ||
A0A8I6ABU2 | A0A8I6ABU2_RAT | Prkca | 667 | ||
A0A8I6G952 | A0A8I6G952_RAT | Prkca | 609 | ||
F1M2P8 | F1M2P8_RAT | Prkca | 636 | ||
F1LS98 | F1LS98_RAT | Prkca | 672 |
Keywords
- Technical term