A0A8I5ZLG1 · A0A8I5ZLG1_RAT
- ProteinPhosphatidylinositol-3-phosphate phosphatase
- GeneMtmr3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1170 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 326-329 | substrate | ||||
Sequence: NRAK | ||||||
Binding site | 351-352 | substrate | ||||
Sequence: NI | ||||||
Active site | 413 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 413-419 | substrate | ||||
Sequence: CSDGWDR |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Molecular Function | phosphoprotein phosphatase activity | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol-3-phosphate phosphatase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZLG1
Proteomes
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 155-576 | Myotubularin phosphatase | ||||
Sequence: EHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRNSCRGFPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVY | ||||||
Region | 587-613 | Disordered | ||||
Sequence: DDSCAPYPAPGTSPDEPPLSRLPKTRS | ||||||
Compositional bias | 697-725 | Basic and acidic residues | ||||
Sequence: TKEESGVEEPTHREHTEVPEVKEEAPLAK | ||||||
Region | 697-735 | Disordered | ||||
Sequence: TKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSG | ||||||
Region | 856-875 | Disordered | ||||
Sequence: ESGPQLHHRPCLASSGRFSG | ||||||
Region | 880-901 | Disordered | ||||
Sequence: PIAPEPRSAERPQWDSVLHRTS | ||||||
Region | 936-975 | Disordered | ||||
Sequence: NKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSHQLS | ||||||
Compositional bias | 992-1010 | Polar residues | ||||
Sequence: KWLNSHSGRPSTTNSPEQP | ||||||
Region | 992-1021 | Disordered | ||||
Sequence: KWLNSHSGRPSTTNSPEQPSRSHLDDDGMP | ||||||
Coiled coil | 1035-1062 | |||||
Sequence: ESGHQQEVETLKKQVQELKSRLESQYLT | ||||||
Domain | 1082-1151 | FYVE-type | ||||
Sequence: DHLAAHCYACDSAFWLASRKHHCRDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLH |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,170
- Mass (Da)130,946
- Last updated2022-05-25 v1
- Checksum629BC6D7A560302F
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q5PQT2 | MTMR3_RAT | Mtmr3 | 1194 | ||
A0A0G2K8C7 | A0A0G2K8C7_RAT | Mtmr3 | 1206 | ||
A0A8I6AAN8 | A0A8I6AAN8_RAT | Mtmr3 | 1207 | ||
A0A8I5ZTK5 | A0A8I5ZTK5_RAT | Mtmr3 | 1198 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 697-725 | Basic and acidic residues | ||||
Sequence: TKEESGVEEPTHREHTEVPEVKEEAPLAK | ||||||
Compositional bias | 992-1010 | Polar residues | ||||
Sequence: KWLNSHSGRPSTTNSPEQP |
Keywords
- Technical term