A0A8I5ZLF0 · A0A8I5ZLF0_RAT
- ProteinYTH domain-containing family protein
- GeneYthdf1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids567 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | P-body | |
Molecular Function | mRNA binding | |
Molecular Function | N6-methyladenosine-containing RNA reader activity | |
Molecular Function | ribosome binding | |
Biological Process | learning | |
Biological Process | memory | |
Biological Process | mRNA destabilization | |
Biological Process | organelle assembly | |
Biological Process | positive regulation of translation | |
Biological Process | positive regulation of translational initiation | |
Biological Process | regulation of antigen processing and presentation | |
Biological Process | regulation of axon guidance | |
Biological Process | regulation of long-term synaptic potentiation | |
Biological Process | regulation of mRNA stability | |
Biological Process | stress granule assembly |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameYTH domain-containing family protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZLF0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 247-373 | Disordered | ||||
Sequence: SKPAKPQPKMKTKSGPIVGGTLPPPPIKHNMDIGTWDNKGPAPKASAPQQTPSPQAAPQPQQVAQPLPVQPPPLVQPQYQSPQQPLQPRWVAPRNRNAAFGQSGGANSDSNSVGSAQPTSAPSVESH | ||||||
Compositional bias | 299-325 | Pro residues | ||||
Sequence: SPQAAPQPQQVAQPLPVQPPPLVQPQY | ||||||
Compositional bias | 346-370 | Polar residues | ||||
Sequence: FGQSGGANSDSNSVGSAQPTSAPSV | ||||||
Domain | 397-531 | YTH | ||||
Sequence: GRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDGAFRSMSSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKII |
Sequence similarities
Belongs to the YTHDF family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length567
- Mass (Da)62,049
- Last updated2022-05-25 v1
- ChecksumC9E0A2D49FBAE8A9
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AL56 | A0A8I6AL56_RAT | Ythdf1 | 552 | ||
F7F2Q6 | F7F2Q6_RAT | Ythdf1 | 586 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 299-325 | Pro residues | ||||
Sequence: SPQAAPQPQQVAQPLPVQPPPLVQPQY | ||||||
Compositional bias | 346-370 | Polar residues | ||||
Sequence: FGQSGGANSDSNSVGSAQPTSAPSV |
Keywords
- Technical term