A0A8I5ZKT4 · A0A8I5ZKT4_RAT

  • Protein
    Long-chain-fatty-acid--CoA ligase
  • Gene
    Acsl5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

Catalytic activity

  • (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
    EC:6.2.1.15 (UniProtKB | ENZYME | Rhea)
  • (E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
    EC:6.2.1.3 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Molecular FunctionATP binding
Molecular Functionlong-chain fatty acid-CoA ligase activity
Biological Processlipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Long-chain-fatty-acid--CoA ligase
  • EC number
  • Alternative names
    • Acyl-CoA synthetase
    • Long-chain acyl-CoA synthetase

Gene names

    • Name
      Acsl5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I5ZKT4

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type III membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Endoplasmic reticulum membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass type III membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain101-473AMP-dependent synthetase/ligase

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    651
  • Mass (Da)
    73,051
  • Last updated
    2022-05-25 v1
  • Checksum
    1DE9C878FE047DC0
MLFIFNFLFSPLPTPALICLLTFGTAIFLWLINRPQPVLPLIDLDNQSVGIEGGARRGAFQKNNDLILYYFSDAKTLYEVFQRGLAVSDNGPCLGYRKPNQPYKWISYKQVSDRAEYLGSCLLHKGYKPSQDQFIGIFAQNRPEWVISELACYTYSMVAVPLYDTLGAEAIIYVINRADISVVICDTPQKATMLIENVEKDLTPGLKTVILMDPFDDDLMKRGEKCGIEMLSLHDAENLGKENFKKPVPPNPEDLSVICFTSGTTGDPKGAMLTHQNIVSNMAAFLKFLEPIFQPTPEDVTISYLPLAHMFERLVQGVIFSCGGKIGFFQGDIRLLPDDMKALKPTVFPTVPRLLNRVYDKVQNEAKTPLKKFLLNLAIISKFNEVRNGIIRRNSLWDKLVFSKIQVFEAYGQTECTAGCSITSPGDWTAGHVGTPVSCNFVKLEDVADMNYFSVNNEGEICIKGNNVFKGYLKDPEKTQEVLDKDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENVYSRSRPILQVFVHGESLRSFLIGVVVPDPESLPSFAAKIGVKGSFEELCQNQCVKKAILEDLQKVGKEGGLKSFEQVKSIFVHPEPFSIENGLLTPTLKAKRVELAKFFQTQIKSLYESIEE

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
O88813ACSL5_RATAcsl5683
F1LPB3F1LPB3_RATAcsl5679
A0A8I6AHE5A0A8I6AHE5_RATAcsl5636
A0A8I6GLI0A0A8I6GLI0_RATAcsl5674
A0A8I6AAN7A0A8I6AAN7_RATAcsl5715
A6JHY8A6JHY8_RATAcsl5683
A0A8I5ZM08A0A8I5ZM08_RATAcsl5681

Keywords

Genome annotation databases

Similar Proteins

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