A0A8I5ZKT4 · A0A8I5ZKT4_RAT
- ProteinLong-chain-fatty-acid--CoA ligase
- GeneAcsl5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids651 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Catalytic activity
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateThis reaction proceeds in the forward direction.
- (E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphateThis reaction proceeds in the forward direction.
- 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateThis reaction proceeds in the forward direction.
- 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphateThis reaction proceeds in the forward direction.
- 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateThis reaction proceeds in the forward direction.
- hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphateThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | mitochondrial outer membrane | |
Molecular Function | ATP binding | |
Molecular Function | long-chain fatty acid-CoA ligase activity | |
Biological Process | lipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLong-chain-fatty-acid--CoA ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZKT4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type III membrane protein
Mitochondrion outer membrane ; Single-pass membrane protein
Endoplasmic reticulum membrane ; Single-pass membrane protein
Mitochondrion outer membrane ; Single-pass type III membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-32 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 101-473 | AMP-dependent synthetase/ligase | |||
Sequence similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length651
- Mass (Da)73,051
- Last updated2022-05-25 v1
- Checksum1DE9C878FE047DC0
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O88813 | ACSL5_RAT | Acsl5 | 683 | ||
F1LPB3 | F1LPB3_RAT | Acsl5 | 679 | ||
A0A8I6AHE5 | A0A8I6AHE5_RAT | Acsl5 | 636 | ||
A0A8I6GLI0 | A0A8I6GLI0_RAT | Acsl5 | 674 | ||
A0A8I6AAN7 | A0A8I6AAN7_RAT | Acsl5 | 715 | ||
A6JHY8 | A6JHY8_RAT | Acsl5 | 683 | ||
A0A8I5ZM08 | A0A8I5ZM08_RAT | Acsl5 | 681 |
Keywords
- Technical term