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A0A8I5ZJA7 · A0A8I5ZJA7_RAT

  • Protein
    alpha-1,2-Mannosidase
  • Gene
    Man1a1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Pathway

Protein modification; protein glycosylation.

Features

Showing features for active site, binding site.

1746100200300400500600700
Type
IDPosition(s)Description
Active site373Proton donor
Active site506
Active site615Proton donor
Active site640
Binding site726Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasmic vesicle
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum-Golgi intermediate compartment
Cellular ComponentGolgi membrane
Molecular Functioncalcium ion binding
Molecular Functionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Biological Processcarbohydrate metabolic process
Biological ProcessERAD pathway
Biological Processprotein targeting to ER

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    alpha-1,2-Mannosidase
  • EC number

Gene names

    • Name
      Man1a1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I5ZJA7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane135-155Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond569↔601

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil207-238

Sequence similarities

Belongs to the glycosyl hydrolase 47 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    746
  • Mass (Da)
    82,163
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    FB8762ED758642FA34EF8504701737E1
MENLTNCDEGLQPAVCRACLFAKGAAPARIAGGEPLPAGRPAAQTRALGGLDAQEPAPQQLTAGGSEVWLLSGSAPDAWTDCQPAAAISGAMPVGGLLPLFSSPGGGGLGGGLGGGLGGGRKGSGPAAFRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLSGVLFHSNPALQPPAEHKPGLGARAEDAAEGRVRHREEGVPGDPGAGLEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKEKVAQDQLRDKDLFGGLPKVDFLPPIGVENREPADATIREKRSKIKEMMAHAWNNYKRYAWGLNELKPISKEGHSSSLFGNIKGATIVDALDTLFIMGMKTEFQEAKSWIKKYLDFNVNAEVSVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHSPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLAHLSGNPVFAEKVMNIRTVLNKLDKPEGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSGGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADGAPEARAQHYLELGAEIARTCHESYNRTYVKLGPEAFRFDGGVEAIATRQNEKYYILRPEVIETYMYMWRLTHDPKYRTWAWEAVEALESHCRVNGGYSGLRDVYIAHESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNTEAHPFPILRDQKKEVDVQEK

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
G3V9N9G3V9N9_RATMan1a1655
A0A0G2JW29A0A0G2JW29_RATMan1a1747
Q7TP80Q7TP80_RATMan1a1246

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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