A0A8I5Y961 · A0A8I5Y961_RAT
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- GenePlcb4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1190 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5Y961
Proteomes
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 487-512 | Disordered | ||||
Sequence: AAPASILEDDNEEEIESADQEEEAHP | ||||||
Compositional bias | 492-507 | Acidic residues | ||||
Sequence: ILEDDNEEEIESADQE | ||||||
Domain | 565-681 | PI-PLC Y-box | ||||
Sequence: LSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMR | ||||||
Domain | 681-807 | C2 | ||||
Sequence: RRPDRTFDPFSETPVDGVIAATCSVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPL | ||||||
Region | 856-902 | Disordered | ||||
Sequence: ETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTAALGSG | ||||||
Compositional bias | 880-901 | Polar residues | ||||
Sequence: KANVTPQSSSELRPTTTAALGS | ||||||
Coiled coil | 920-983 | |||||
Sequence: LKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKK | ||||||
Region | 1078-1106 | Disordered | ||||
Sequence: KISMENSKAISQDKSIKNKAERERRVREL | ||||||
Compositional bias | 1089-1106 | Basic and acidic residues | ||||
Sequence: QDKSIKNKAERERRVREL | ||||||
Region | 1155-1190 | Disordered | ||||
Sequence: HAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN | ||||||
Compositional bias | 1174-1190 | Polar residues | ||||
Sequence: RDGPQTSNSSMKLQNAN |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,190
- Mass (Da)135,770
- Last updated2022-05-25 v1
- Checksum8FC763CB1E4525AF
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9QW07 | PLCB4_RAT | Plcb4 | 1175 | ||
F1LNK2 | F1LNK2_RAT | Plcb4 | 1176 | ||
D3ZCI6 | D3ZCI6_RAT | Plcb4 | 1022 | ||
A0A8I6AGH0 | A0A8I6AGH0_RAT | Plcb4 | 1170 | ||
A0A8I6A4W1 | A0A8I6A4W1_RAT | Plcb4 | 1181 | ||
D4A8C5 | D4A8C5_RAT | Plcb4 | 1206 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 492-507 | Acidic residues | ||||
Sequence: ILEDDNEEEIESADQE | ||||||
Compositional bias | 880-901 | Polar residues | ||||
Sequence: KANVTPQSSSELRPTTTAALGS | ||||||
Compositional bias | 1089-1106 | Basic and acidic residues | ||||
Sequence: QDKSIKNKAERERRVREL | ||||||
Compositional bias | 1174-1190 | Polar residues | ||||
Sequence: RDGPQTSNSSMKLQNAN |
Keywords
- Technical term