A0A8I5QKL9 · A0A8I5QKL9_HUMAN

  • Protein
    Myosin light chain kinase, smooth muscle
  • Gene
    MYLK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

116602004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Binding site1239ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin cytoskeleton
Molecular FunctionATP binding
Molecular Functioncalmodulin binding
Molecular Functionprotein kinase activity
Biological Processmuscle structure development
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Myosin light chain kinase, smooth muscle
  • EC number
  • Alternative names
    • Telokin

Gene names

    • Name
      MYLK

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8I5QKL9

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)357PRIDEPhosphotyrosine
Modified residue (large scale data)693PRIDEPhosphoserine
Modified residue (large scale data)837PRIDEPhosphoserine
Modified residue (large scale data)897PRIDEPhosphoserine
Modified residue (large scale data)1083PRIDEPhosphothreonine
Modified residue (large scale data)1184PRIDEPhosphoserine
Modified residue (large scale data)1316PRIDEPhosphoserine
Modified residue (large scale data)1363PRIDEPhosphoserine
Modified residue (large scale data)1505PRIDEPhosphoserine
Modified residue (large scale data)1506PRIDEPhosphoserine
Modified residue (large scale data)1514PRIDEPhosphoserine
Modified residue (large scale data)1518PRIDEPhosphoserine
Modified residue (large scale data)1519PRIDEPhosphoserine
Modified residue (large scale data)1520PRIDEPhosphothreonine
Modified residue (large scale data)1522PRIDEPhosphoserine
Modified residue (large scale data)1524PRIDEPhosphothreonine
Modified residue (large scale data)1525PRIDEPhosphoserine
Modified residue (large scale data)1534PRIDEPhosphoserine
Modified residue (large scale data)1539PRIDEPhosphoserine
Modified residue (large scale data)1594PRIDEPhosphoserine
Modified residue (large scale data)1598PRIDEPhosphoserine

Keywords

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain33-122Ig-like
Domain161-249Ig-like
Domain260-345Ig-like
Domain366-457Ig-like
Domain467-554Ig-like
Region678-844Disordered
Compositional bias681-695Basic and acidic residues
Compositional bias741-768Polar residues
Compositional bias804-834Basic and acidic residues
Domain844-932Ig-like
Region938-983Disordered
Domain984-1072Ig-like
Domain1080-1172Fibronectin type-III
Region1159-1192Disordered
Domain1210-1465Protein kinase
Compositional bias1513-1529Polar residues
Region1513-1533Disordered
Domain1555-1644Ig-like

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,660
  • Mass (Da)
    182,972
  • Last updated
    2022-05-25 v1
  • Checksum
    549531FFE71C6A13
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE

Computationally mapped potential isoform sequences

There are 20 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q15746MYLK_HUMANMYLK1914
A0A8I5QKW8A0A8I5QKW8_HUMANMYLK690
A0A8I5QJT9A0A8I5QJT9_HUMANMYLK625
A0A8I5QJW9A0A8I5QJW9_HUMANMYLK720
A0A8J9G5A3A0A8J9G5A3_HUMANMYLK82
F8WBL7F8WBL7_HUMANMYLK70
D6R9C2D6R9C2_HUMANMYLK229
A0A8I5KS78A0A8I5KS78_HUMANMYLK76
A0A8I5KQY6A0A8I5KQY6_HUMANMYLK251
A0A8I5KTQ1A0A8I5KTQ1_HUMANMYLK713
A0A8I5KU53A0A8I5KU53_HUMANMYLK1924
A0A8I5KUP2A0A8I5KUP2_HUMANMYLK953
A0A8I5KUH4A0A8I5KUH4_HUMANMYLK476
A0A8I5KUB2A0A8I5KUB2_HUMANMYLK924
A0A8I5KVV3A0A8I5KVV3_HUMANMYLK31
A0A8I5KYA1A0A8I5KYA1_HUMANMYLK83
A0A8I5KYB9A0A8I5KYB9_HUMANMYLK59
A0A8I5KYZ0A0A8I5KYZ0_HUMANMYLK462
A0A8I5KZ33A0A8I5KZ33_HUMANMYLK47
A0A8I5KXG8A0A8I5KXG8_HUMANMYLK442

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias681-695Basic and acidic residues
Compositional bias741-768Polar residues
Compositional bias804-834Basic and acidic residues
Compositional bias1513-1529Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC020634
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC023165
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC117381
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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