A0A8I5KU01 · A0A8I5KU01_HUMAN

  • Protein
    E3 ubiquitin-protein ligase
  • Gene
    HECTD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

122472004006008001,0001,2001,4001,6001,8002,0002,200
TypeIDPosition(s)Description
Active site2216Glycyl thioester intermediate

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionubiquitin protein ligase activity
Biological Processprotein ubiquitination
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase
  • EC number

Gene names

    • Name
      HECTD1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8I5KU01

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,484 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)248PRIDEPhosphoserine
Modified residue (large scale data)252PRIDEPhosphoserine
Modified residue (large scale data)357PRIDEPhosphoserine
Modified residue (large scale data)358PRIDEPhosphoserine
Modified residue (large scale data)481PRIDEPhosphoserine
Modified residue (large scale data)631PRIDEPhosphoserine
Modified residue (large scale data)632PRIDEPhosphoserine
Modified residue (large scale data)640PRIDEPhosphoserine
Modified residue (large scale data)710PRIDEPhosphoserine
Modified residue (large scale data)1481PRIDEPhosphothreonine
Modified residue (large scale data)1493PRIDEPhosphoserine
Modified residue (large scale data)1521PRIDEPhosphothreonine
Modified residue (large scale data)1666PRIDEPhosphoserine

Keywords

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, repeat, domain.

TypeIDPosition(s)Description
Region246-269Disordered
Compositional bias252-269Polar residues
Repeat395-427ANK
Repeat426-458ANK
Compositional bias489-512Basic and acidic residues
Region489-513Disordered
Region627-657Disordered
Region707-748Disordered
Compositional bias733-748Polar residues
Domain1266-1346MIB/HERC2
Region1288-1341Disordered
Compositional bias1312-1341Polar residues
Region1395-1478Disordered
Compositional bias1396-1421Acidic residues
Compositional bias1422-1442Basic and acidic residues
Compositional bias1464-1478Basic and acidic residues
Region1498-1518Disordered
Domain1872-2207HECT
Region2018-2039Disordered
Domain2211-2247HECT

Sequence similarities

Belongs to the UPL family. K-HECT subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,247
  • Mass (Da)
    251,381
  • Last updated
    2022-05-25 v1
  • Checksum
    766EC67D9499F7B3
MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDESAPDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELICTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVESLSSLLKHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGGTVSGPSSACKPGRSTTGAPSTTADSKLSNQVSTIVSLLSTLCRGSPVVTHDLLRSELPDSIESALQGDERCVLDTMRLVDLLLVLLFEGRKALPKSSAGSTGRIPGLRRLDSSGERSHRQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQRSSSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQSPGDWMCPVNKGDDKKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSIRKASLALIRKMIHFCSEALLKEVCDSDVGHNLPTILVEITATVLDQEDDDDGHLLALQIIRDLVDKGGDIFLDQLARLGVISKVSTLAGPSSDDENEEESKPEKEDEPQEDAKELQQGKPYHWRDWSIIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSESRSEFLEKLQRARGQVKPSTSSQPILSAPGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATILKEDLPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDLYDDHFKAVESMPRGVVVTLRNIATQLESSWELHTNRQCIESENTWRDLMKTALENLIVLLKDENTISPYEMCSSGLVQALLTVLNNSMDLDMKQDCSQLVERINVFKTAFSENEDDESRPAVALIRKLIAVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERAPGETALIDRTGRMLKMEPLATVESLEQYLLKMVAKQWYDFDRSSFVFVRKLREGQNFIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYGLVVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWFAIDLGLWVIPSAYTLRHARGYGRSALRNWVFQVSKDGQNWTSLYTHVDDCSLNEPGSTATWPLDPPKDEKQGWRHVRIKQMGKNASGQTHYLSLSGFELYGTVNGVCEDQLGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTVTGELHNASPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPAGAGSRPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPHSELLEEVECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGTNKSIRKNRNCSQLIAAYKDFCEHGTKSGLNQGAISTLQSSDILNLTKEQPQAKAGNGQNSCGVEDVLQLLRILYIVASDPYSRISQEDGDEQPQFTFPPDEFTSKKITTKILQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQRTDLGAWLCDDNFPDDESRHVDLGGGLKPPGYYVQRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSEDEKNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERLLAATMEKGFHLN

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9ULT8HECD1_HUMANHECTD12610
A0A8I5QJE9A0A8I5QJE9_HUMANHECTD181
A0A8I5QJU2A0A8I5QJU2_HUMANHECTD12563
H0YJP0H0YJP0_HUMANHECTD12520
H0YJD4H0YJD4_HUMANHECTD12329
H0YJ72H0YJ72_HUMANHECTD1122
G3V4V5G3V4V5_HUMANHECTD1391
A0A8I5KUD6A0A8I5KUD6_HUMANHECTD11176
A0A087X2H1A0A087X2H1_HUMANHECTD12608

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias252-269Polar residues
Compositional bias489-512Basic and acidic residues
Compositional bias733-748Polar residues
Compositional bias1312-1341Polar residues
Compositional bias1396-1421Acidic residues
Compositional bias1422-1442Basic and acidic residues
Compositional bias1464-1478Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL121808
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL136418
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KC877516
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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