A0A8I5KTS5 · A0A8I5KTS5_HUMAN

  • Protein
    Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase
  • Gene
    POMGNT1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular ComponentGolgi membrane
Molecular Functionacetylglucosaminyltransferase activity
Molecular Functioncarbohydrate binding
Molecular Functionmanganese ion binding
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase
  • EC number
  • Short names
    POMGnT1

Gene names

    • Name
      POMGNT1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8I5KTS5

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus membrane
; Single-pass type II membrane protein

Keywords

Disease & Variants

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)7PRIDEPhosphoserine
Modified residue (large scale data)66PRIDEPhosphoserine
Modified residue (large scale data)78PRIDEPhosphotyrosine

Keywords

Proteomic databases

Interaction

Subunit

Interacts with DAG1 (via O-linked mannose moiety). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region68-96Disordered
Compositional bias78-96Basic and acidic residues
Domain129-218ILEI/PANDER

Domain

The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

Sequence similarities

Belongs to the glycosyltransferase 13 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    527
  • Mass (Da)
    60,047
  • Last updated
    2022-05-25 v1
  • Checksum
    9E3B7F2395D1A909
MDDWKPSPLIKPFGARKKRSWYLTWKYKLTNQRALRRFCQTGAVLFLLVTVIVNIKLILDTRRAISEANEDPEPEQDYDEALGRLEPPRRRGSGPRRVLDVEVYSSRSKVYVAVDGTTVLEDEAREQGRGIHVIVLNQATGHVMAKRVFDTYSPHEDEAMVLFLNMVAPGRVLICTVKDEGSFHLKDTAKALLRSLGSQAGPALGWRDTWAFVGRKGGPVFGEKHSKSPALSSWGDPVLLKTDVPLSSAEEAECHWADTELNRRRRRFCSKVEGYGSVCSCKDPTPIEFSPDPLPDNKVLNVPVAVIAGNRPNYLYRMLRSLLSAQGVSPQMITVFIDGYYEEPMDVVALFGLRGIQHTPISIKNARVSQHYKASLTATFNLFPEAKFAVVLEEDLDIAVDFFSFLSQSIHLLEEDDSLYCISAWNDQGYEHTAEDPALLYRVETMPGLGWVLRRSLYKEELEPKWPTPEKLWDWDMWMRMPEQRRGRECIIPDVSRSYHFGIVGLNMNGYFHEAYFKKHKFNTVPV

Computationally mapped potential isoform sequences

There are 10 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8WZA1PMGT1_HUMANPOMGNT1660
A0A8I5QJA9A0A8I5QJA9_HUMANPOMGNT1317
A0A8I5QJV3A0A8I5QJV3_HUMANPOMGNT1546
Q68CV6Q68CV6_HUMANPOMGNT1200
A0A8I5KNB7A0A8I5KNB7_HUMANPOMGNT1718
A0A8I5KPT5A0A8I5KPT5_HUMANPOMGNT182
A0A8I5KQE4A0A8I5KQE4_HUMANPOMGNT1327
A0A8I5KR25A0A8I5KR25_HUMANPOMGNT1627
A0A8I5KSR6A0A8I5KSR6_HUMANPOMGNT147
A0A8I5KVA5A0A8I5KVA5_HUMANPOMGNT1673

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias78-96Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL672043
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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