A0A8I5KSH6 · A0A8I5KSH6_HUMAN

  • Protein
    ATP-dependent RNA helicase
  • Gene
    DDX10
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

RNA helicase.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent RNA helicase
  • EC number

Gene names

    • Name
      DDX10

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8I5KSH6

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 971 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)4PRIDEPhosphothreonine
Modified residue (large scale data)7PRIDEPhosphoserine
Modified residue (large scale data)10PRIDEPhosphoserine
Modified residue (large scale data)52PRIDEPhosphoserine
Modified residue (large scale data)197PRIDEPhosphothreonine
Modified residue (large scale data)589PRIDEPhosphoserine
Modified residue (large scale data)627PRIDEPhosphothreonine
Modified residue (large scale data)656PRIDEPhosphoserine
Modified residue (large scale data)660PRIDEPhosphothreonine
Modified residue (large scale data)661PRIDEPhosphoserine
Modified residue (large scale data)767PRIDEPhosphothreonine
Modified residue (large scale data)830PRIDEPhosphoserine
Modified residue (large scale data)853PRIDEPhosphoserine
Modified residue (large scale data)854PRIDEPhosphoserine
Modified residue (large scale data)857PRIDEPhosphoserine
Modified residue (large scale data)859PRIDEPhosphoserine
Modified residue (large scale data)879PRIDEPhosphoserine
Modified residue (large scale data)881PRIDEPhosphoserine
Modified residue (large scale data)890PRIDEPhosphoserine

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain, motif.

TypeIDPosition(s)Description
Region1-43Disordered
Compositional bias20-40Basic residues
Domain69-97DEAD-box RNA helicase Q
Motif69-97Q motif
Domain100-274Helicase ATP-binding
Domain337-498Helicase C-terminal
Compositional bias612-628Basic and acidic residues
Region612-681Disordered
Compositional bias653-667Polar residues
Region753-900Disordered
Compositional bias757-793Basic and acidic residues
Compositional bias804-825Basic and acidic residues
Compositional bias826-842Acidic residues
Compositional bias843-900Basic and acidic residues

Domain

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similarities

Belongs to the DEAD box helicase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    925
  • Mass (Da)
    106,382
  • Last updated
    2022-05-25 v1
  • Checksum
    6F5A2E2D92CACC6E
MGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYRLPVHSDGSNQRDSVGVGPSEPGVGYSLVVRRFLSRSEKRNIRVGVTRFSSTPATLEQNYIVCELQQKISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQKKVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKEVFDVSKLPIPEYALSLGLAVAPRVRFLQKMQKQPTKELVRSQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQKGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAKGSQAPSLPNTSEAQKIKEVPTQFLDRDEEEEDADFLKVKRHNVFGLDLKDEKTLQKKEPSKSSIKKKMTKVAEAKKVMKRNFKVNKKITFTDEGELVQQWPQMQKSAIKDAEEDDDTGGINLHKAKERLQEEDKFDKEEYRKKIKAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDDDGFDPSTLPDPDKYRSSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTSHNRKKARWDTLEPLDTGLSLAEDEELVLHLLRSQS

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q13206DDX10_HUMANDDX10875
E9PIF2E9PIF2_HUMANDDX10835
A0A3B3ISR7A0A3B3ISR7_HUMANDDX10679
A0A8I5KPM1A0A8I5KPM1_HUMANDDX10482
A0A8I5KQZ1A0A8I5KQZ1_HUMANDDX10676
A0A8I5KUU7A0A8I5KUU7_HUMANDDX10489
A0A8I5KXY1A0A8I5KXY1_HUMANDDX10451

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias20-40Basic residues
Compositional bias612-628Basic and acidic residues
Compositional bias653-667Polar residues
Compositional bias757-793Basic and acidic residues
Compositional bias804-825Basic and acidic residues
Compositional bias826-842Acidic residues
Compositional bias843-900Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP002453
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AP003027
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AP003387
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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