A0A8I4RSM0 · A0A8I4RSM0_MOUSE
- ProteinVoltage-dependent L-type calcium channel subunit alpha
- GeneCacna1s
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1850 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent L-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A8I4RSM0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 55-72 | Helical | ||||
Sequence: TIILLTIFANCVALAVYL | ||||||
Transmembrane | 92-112 | Helical | ||||
Sequence: FFLIVFSIEAAMKIIAYGFLF | ||||||
Transmembrane | 124-145 | Helical | ||||
Sequence: VLDFIIVFLGVFTVILEQVNII | ||||||
Transmembrane | 196-218 | Helical | ||||
Sequence: LFHIALLVLFMVIIYAIIGLELF | ||||||
Transmembrane | 278-299 | Helical | ||||
Sequence: FGFSMLTVYQCISMEGWTDVLY | ||||||
Transmembrane | 311-333 | Helical | ||||
Sequence: WIYFVTLILLGSFFILNLVLGVL | ||||||
Transmembrane | 433-450 | Helical | ||||
Sequence: VFYWLVILIVALNTLSIA | ||||||
Transmembrane | 470-488 | Helical | ||||
Sequence: VLLTLFTIEMLMKMYGLGL | ||||||
Transmembrane | 562-581 | Helical | ||||
Sequence: LLLLLFLFIIIFALLGMQLF | ||||||
Transmembrane | 634-661 | Helical | ||||
Sequence: GVLVCIYFIILFVCGNYILLNVFLAIAV | ||||||
Transmembrane | 795-817 | Helical | ||||
Sequence: IVNATWFTNFILLFILLSSAALA | ||||||
Transmembrane | 837-858 | Helical | ||||
Sequence: YVFTAVFTVEIVLKMTTYGAFL | ||||||
Transmembrane | 916-945 | Helical | ||||
Sequence: HVVQCVFVAIRTIGNIVLVTTLLQFMFACI | ||||||
Transmembrane | 1042-1068 | Helical | ||||
Sequence: AIFFIIYIILIAFFMMNIFVGFVIVTF | ||||||
Transmembrane | 1122-1140 | Helical | ||||
Sequence: YLMFALIMLNTICLGMQHY | ||||||
Transmembrane | 1152-1170 | Helical | ||||
Sequence: ILNVAFTIIFTLEMVLKLI | ||||||
Transmembrane | 1182-1199 | Helical | ||||
Sequence: WNVFDFLIVIGSIIDVIL | ||||||
Transmembrane | 1266-1284 | Helical | ||||
Sequence: ALPYVALLIVMLFFIYAVI | ||||||
Transmembrane | 1357-1381 | Helical | ||||
Sequence: AYYYFISFYMLCAFLIINLFVAVIM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Glycosylation | 79 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 257 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-20 | Basic and acidic residues | ||||
Sequence: MEPPSPQDEGLRKKQPKKPV | ||||||
Region | 1-23 | Disordered | ||||
Sequence: MEPPSPQDEGLRKKQPKKPVPEI | ||||||
Compositional bias | 675-710 | Basic and acidic residues | ||||
Sequence: KAKAEERKRRKMSKGLPDKSEEERATVTKKLEQKSK | ||||||
Region | 675-712 | Disordered | ||||
Sequence: KAKAEERKRRKMSKGLPDKSEEERATVTKKLEQKSKGE | ||||||
Region | 731-757 | Disordered | ||||
Sequence: EVKDPYPSADFPGDDEEDEPEIPVSPR | ||||||
Domain | 1515-1548 | Voltage-dependent calcium channel alpha-1 subunit IQ | ||||
Sequence: DDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRP | ||||||
Region | 1702-1721 | Disordered | ||||
Sequence: GPLSQPCRASGPHSRSHVDK | ||||||
Region | 1727-1765 | Disordered | ||||
Sequence: TQRGMPEGQVPPSPCQLSQAEHPVQKEGKGPTSRFLETP |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,850
- Mass (Da)210,192
- Last updated2022-05-25 v1
- Checksum35E1C0EC26855634
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-20 | Basic and acidic residues | ||||
Sequence: MEPPSPQDEGLRKKQPKKPV | ||||||
Compositional bias | 675-710 | Basic and acidic residues | ||||
Sequence: KAKAEERKRRKMSKGLPDKSEEERATVTKKLEQKSK |
Keywords
- Technical term