A0A8I3Q8L3 · A0A8I3Q8L3_CANLF
- Proteinnon-specific serine/threonine protein kinase
- GeneNEK4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids794 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Biological Process | DNA damage response | |
Biological Process | mitotic cell cycle | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | regulation of cellular senescence |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8I3Q8L3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-261 | Protein kinase | ||||
Sequence: YCYLRVVGRGSYGEVTLVRHRRDGRQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKERKGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENNGDMANTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKDYSPELSELIRTMLSKRPEERPSVRSILRQPYI | ||||||
Region | 296-316 | Disordered | ||||
Sequence: SGNAESSHKVVPLQPQSSEGS | ||||||
Compositional bias | 380-397 | Basic and acidic residues | ||||
Sequence: SDGLVRENQPRHLDTSNE | ||||||
Region | 380-530 | Disordered | ||||
Sequence: SDGLVRENQPRHLDTSNELEGKCSISQVKEKLQDGTEPSAQPRNVIPAWFSNDVTGERSDPARPLQPLNKDQKPKDQDQVANECVTEKPDRTLSGLQPHSFGSEPSLSRQRRQKKREQPKHSGEERQVSRDLCRFQEAPPRLLPSLPTAGK | ||||||
Compositional bias | 398-427 | Polar residues | ||||
Sequence: LEGKCSISQVKEKLQDGTEPSAQPRNVIPA | ||||||
Compositional bias | 448-464 | Basic and acidic residues | ||||
Sequence: NKDQKPKDQDQVANECV | ||||||
Compositional bias | 487-511 | Basic and acidic residues | ||||
Sequence: SRQRRQKKREQPKHSGEERQVSRDL | ||||||
Region | 553-614 | Disordered | ||||
Sequence: SSLRSKEVSSSKDQPLSARERRRLKQSQEEMFPSGPSVRRSLSASGPGNSQEEGQPTPALWS | ||||||
Compositional bias | 565-580 | Basic and acidic residues | ||||
Sequence: DQPLSARERRRLKQSQ | ||||||
Compositional bias | 582-614 | Polar residues | ||||
Sequence: EMFPSGPSVRRSLSASGPGNSQEEGQPTPALWS | ||||||
Region | 631-658 | Disordered | ||||
Sequence: EDELSSSTSSTDKSDGDSKERKCHTNEM | ||||||
Compositional bias | 643-657 | Basic and acidic residues | ||||
Sequence: KSDGDSKERKCHTNE |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length794
- Mass (Da)89,705
- Last updated2022-05-25 v1
- ChecksumC9C360DEE0F0828A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I3S7B7 | A0A8I3S7B7_CANLF | NEK4 | 705 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 380-397 | Basic and acidic residues | ||||
Sequence: SDGLVRENQPRHLDTSNE | ||||||
Compositional bias | 398-427 | Polar residues | ||||
Sequence: LEGKCSISQVKEKLQDGTEPSAQPRNVIPA | ||||||
Compositional bias | 448-464 | Basic and acidic residues | ||||
Sequence: NKDQKPKDQDQVANECV | ||||||
Compositional bias | 487-511 | Basic and acidic residues | ||||
Sequence: SRQRRQKKREQPKHSGEERQVSRDL | ||||||
Compositional bias | 565-580 | Basic and acidic residues | ||||
Sequence: DQPLSARERRRLKQSQ | ||||||
Compositional bias | 582-614 | Polar residues | ||||
Sequence: EMFPSGPSVRRSLSASGPGNSQEEGQPTPALWS | ||||||
Compositional bias | 643-657 | Basic and acidic residues | ||||
Sequence: KSDGDSKERKCHTNE |
Keywords
- Technical term