A0A8I3Q0F1 · A0A8I3Q0F1_CANLF
- ProteinAutophagy-related protein 9
- GeneATG9A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids874 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death.
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
- a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | autophagosome membrane | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | late endosome membrane | |
Cellular Component | mitochondrion | |
Cellular Component | phagophore assembly site membrane | |
Cellular Component | recycling endosome membrane | |
Cellular Component | trans-Golgi network | |
Molecular Function | phospholipid scramblase activity | |
Biological Process | autophagosome assembly |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAutophagy-related protein 9
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8I3Q0F1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
Late endosome membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Preautophagosomal structure membrane ; Multi-pass membrane protein
Recycling endosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 325-349 | Helical | |||
Transmembrane | 415-432 | Helical | |||
Transmembrane | 439-460 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-24 | Disordered | |||
Region | 691-721 | Disordered | |||
Region | 754-874 | Disordered | |||
Compositional bias | 755-775 | Basic and acidic residues | |||
Compositional bias | 853-874 | Basic and acidic residues | |||
Sequence similarities
Belongs to the ATG9 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length874
- Mass (Da)97,408
- Last updated2022-05-25 v1
- Checksum6BC352F3B741AFC2
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I3QTY0 | A0A8I3QTY0_CANLF | ATG9A | 839 | ||
A0A8I3QK52 | A0A8I3QK52_CANLF | ATG9A | 774 | ||
A0A8I3S775 | A0A8I3S775_CANLF | ATG9A | 857 | ||
A0A8I3SCD1 | A0A8I3SCD1_CANLF | ATG9A | 837 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 755-775 | Basic and acidic residues | |||
Compositional bias | 853-874 | Basic and acidic residues | |||
Keywords
- Technical term