A0A8I3Q0F1 · A0A8I3Q0F1_CANLF

Function

function

Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death.
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentautophagosome membrane
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentlate endosome membrane
Cellular Componentmitochondrion
Cellular Componentphagophore assembly site membrane
Cellular Componentrecycling endosome membrane
Cellular Componenttrans-Golgi network
Molecular Functionphospholipid scramblase activity
Biological Processautophagosome assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 9

Gene names

    • Name
      ATG9A

Organism names

  • Taxonomic identifier
  • Strain
    • Labrador retriever
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis

Accessions

  • Primary accession
    A0A8I3Q0F1

Proteomes

Subcellular Location

Cytoplasmic vesicle, autophagosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane
; Multi-pass membrane protein
Late endosome membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein
Preautophagosomal structure membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane325-349Helical
Transmembrane415-432Helical
Transmembrane439-460Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-24Disordered
Region691-721Disordered
Region754-874Disordered
Compositional bias755-775Basic and acidic residues
Compositional bias853-874Basic and acidic residues

Sequence similarities

Belongs to the ATG9 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    874
  • Mass (Da)
    97,408
  • Last updated
    2022-05-25 v1
  • Checksum
    6BC352F3B741AFC2
MSGQYSTDQRKYAEPPCLSPTAASLPRAWPPLSGGWVGRRAGFLLSPLPTLWGLTPSPPAAAEPGHQGLECGADAVHGAGGQRGQGAVVMAQFDTEYQRLEASYSDSPPGEEDLLVHVPEGSKSPWHHIENLDLFFSRVYNLHQKNGFTCMLIGEVFELMIQENGSLITILVIAGVFWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEAVFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSGGQTEASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAAGLAQGGLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPLPRDLQGSRHRAEVASALRSFSPLHPGQVPAGRAPSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQAQAEPERHVWHRRESDESGESAPEEGGEGSRASQPIPRSASYPCAAPRPGAPETTALQGGFQRRYGGITDPGTVPRAPSHFSRLPLGGWAEDGQSASRHPEPVPEEGSEDELPPQVHKV

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I3QTY0A0A8I3QTY0_CANLFATG9A839
A0A8I3QK52A0A8I3QK52_CANLFATG9A774
A0A8I3S775A0A8I3S775_CANLFATG9A857
A0A8I3SCD1A0A8I3SCD1_CANLFATG9A837

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias755-775Basic and acidic residues
Compositional bias853-874Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

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