A0A8I2DSG7 · A0A8I2DSG7_9ACTN

  • Protein
    Succinate--CoA ligase [ADP-forming] subunit alpha
  • Gene
    sucD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site17-20CoA (UniProtKB | ChEBI)
Binding site43CoA (UniProtKB | ChEBI)
Binding site100-102CoA (UniProtKB | ChEBI)
Binding site165substrate; ligand shared with subunit beta
Active site251Tele-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentsuccinate-CoA ligase complex (ADP-forming)
Molecular Functionnucleotide binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit alpha
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit alpha
      (SCS-alpha
      )

Gene names

    • Name
      sucD
    • ORF names
      KBZ94_01935

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RM72
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A8I2DSG7

Proteomes

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-104CoA-binding

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    294
  • Mass (Da)
    30,253
  • Last updated
    2022-01-19 v1
  • Checksum
    87D4DC801CAE8F08
MAIWLNKDSKVIVQGMTGATGMKHTKLMLGDGTEVVGGVNPRKAGTTVDFDGNEVPVFGTVKEAIEKTGANVSVIFVPEKFTKDAVVEAIDAEIPLAVVITEGIAVHDSAAFWSYAGKKGNKTRIIGPNCPGIITPGQSNVGIIPGDITKPGRIGLVSKSGTLTYQMMYELRDIGFSTAVGIGGDPIIGTTHIDALAAFEADPETDLIVMIGEIGGDAEERAAEYISKNVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPTETAKLARAILAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAGPYH010000002
EMBL· GenBank· DDBJ
MBQ0883701.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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