A0A8I1G487 · A0A8I1G487_9GAMM

  • Protein
    Xanthine-guanine phosphoribosyltransferase
  • Gene
    gpt
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site41-425-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site95-1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site96Mg2+ (UniProtKB | ChEBI)
Binding site99guanine (UniProtKB | ChEBI)
Binding site99xanthine (UniProtKB | ChEBI)
Binding site99-103GMP (UniProtKB | ChEBI)
Binding site141-142GMP (UniProtKB | ChEBI)
Binding site142guanine (UniProtKB | ChEBI)
Binding site142xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • ORF names
      JHC11_05490

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KJE-2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Idiomarinaceae > Idiomarina

Accessions

  • Primary accession
    A0A8I1G487

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-152Phosphoribosyltransferase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    161
  • Mass (Da)
    18,298
  • Last updated
    2022-01-19 v1
  • Checksum
    507772F06C592E94
MGWHSNREFFVSWEELHRATRELARRQLPAEQYKGIIAVSRGGLVPAAIVARELNIRVVDCVAVSSYDHTEQRDDLQVMKDVTATTDGEGFLVVDDLVDTGNTLKFLRDRLPKAKFVTVYAKPAGMELVDDFVADLAQDTWIHFPWDMHLHYIEPLAGQES

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEMOP010000002
EMBL· GenBank· DDBJ
MBJ7315444.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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