A0A8H9Z3U7 · A0A8H9Z3U7_9PSED
- ProteinOxygen-dependent choline dehydrogenase
- GenebetA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids565 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
Catalytic activity
- betaine aldehyde + NAD+ + H2O = glycine betaine + NADH + 2 H+
Cofactor
Pathway
Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 6-35 | FAD (UniProtKB | ChEBI) | |||
Active site | 475 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | choline dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Biological Process | glycine betaine biosynthetic process from choline |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOxygen-dependent choline dehydrogenase
- EC number
- Short namesCDH ; CHD
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A8H9Z3U7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 84-107 | Glucose-methanol-choline oxidoreductase N-terminal | |||
Domain | 261-275 | Glucose-methanol-choline oxidoreductase N-terminal | |||
Sequence similarities
Belongs to the GMC oxidoreductase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length565
- Mass (Da)62,539
- Last updated2022-01-19 v1
- MD5 ChecksumB6D982E3D9CE89B2ED9F95F6E2679481
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JABWRI010000001 EMBL· GenBank· DDBJ | MBC3433831.1 EMBL· GenBank· DDBJ | Genomic DNA |