A0A8H8MVE3 · A0A8H8MVE3_9AGAM

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site15ATP (UniProtKB | ChEBI)
Binding site108-113ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentmRNA cleavage factor complex
Molecular Function5'-3' exonuclease activity
Molecular Function5'-flap endonuclease activity
Molecular FunctionATP binding
Molecular Functionflap-structured DNA binding
Molecular Functionmetal ion binding
Biological Processinterstrand cross-link repair
Biological ProcessmRNA 3'-end processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • Name
      CLP1
    • ORF names
      RhiLY_00528

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AG-Ba
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Cantharellales > Ceratobasidiaceae > Ceratobasidium

Accessions

  • Primary accession
    A0A8H8MVE3

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region633-660Disordered
Domain1144-1259VRR-NUC
Region1263-1423Disordered
Compositional bias1267-1297Polar residues
Compositional bias1360-1376Basic and acidic residues
Compositional bias1379-1393Polar residues
Region1475-1616Disordered
Compositional bias1527-1545Polar residues

Sequence similarities

Belongs to the Clp1 family. Clp1 subfamily.
Belongs to the FAN1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,616
  • Mass (Da)
    178,960
  • Last updated
    2022-01-19 v1
  • Checksum
    D58E9A63CC997500
MSDSTRTWNLSPKTEYRFELEANVSLAIRLNSGNAEIFGAELAPGRLYLFGGRPSTEYTSDETPMVPLINIHTAFEQMRVLAHRALTANQSETAKTRPPRVLVLGPENSGKTSACKTWCNYAVRGRGVSNTCEPGCCGVPGTISACPLSAAIPTCTPANPFGATATSAPTALSSSALLPVVYWFGHTDVKRNKQLMERLIHNLADSVKQKFKQDHTLNASGYIIDSPAAFAIPGPQMENRYNFVKTCVDAFDVNVILVMGNEKLNVEIQRMFGSSGNITILKVPKSGGVVELDYAYQSRVISSQIRAYFYGTPLYLPPSMNATMAQLGGEAATDMTLSPFSTTLDANELRIYRIGDTTLAPTSALPIGATRAIGEMQPVRVDVSSGGLLHSVLALLAPFDSDPSDEALLKQEVSGFLIVTAINMQQRKITVLSPSSGSLSGRVALAGSLEWQDRSSSNENNVALIFSKSADFNPSIVEKSSTELSEIFLGSEPGEGDSKSQQSDIEAIKEEIKESMYVVKLLEMIDTVLEYEAHLFSGSERELLQQIQTVDSVQQFLISRLVQRKRGKWHRVDNLLSSYQRDFVKYLQISEADTPSRMAQALIALCTNWRTQQGPSFAAPSPKDIIDLTLDSDDEASDEKPSVADLPQPAPLSTSDSDSSACSFAEDTNVATPTELLECLTLDELKVVAKRSKIARTKQTRQELIKALLHSSSTQTTLPFTVVKKPSKASLQKGKTAIRRFFVQAPTSKMPLQERRVRDTCYEIFGACFRLRDEVFRVLHLYSGSESIMLSAILATAQMRNYPLYEYRRTTDIFKTRADMIRYTDSLRLQGEIDDILGEGPAGWVAGVKYDRLEAARQVIGRWKQIWDRWNTLVTYFKDKPPCNRGLERFEDGHILTRIVSKAAHCFGLLKDYDMELKLREALVRQTRWRRGKRGGWYDRIALVYTRYMGGGDANLKKARDVLLQALGEELVNIGSRPKLLKRLRKLEKQLRLPPEEHYASDLELRIATLTTIEGVRIFTPPFPSHTKDMTPDKNADGQKPLVILDSKPRPVHKGKSVWVGKEGEVNVETLALEYYATLGFKGFHSEGSIISTLFGLLFWDILFAPVPGAFETPYQSAPLDLFHDSFVSAREDIVKARIKQLLEDEGAARRLIEAVDERERPNETWCIGVRWDQFEREALVEIVECLGGRALATICQLLAEYAYRGGGVPDLFIWNYAEKTCKFVEVKGPGDQLSETQKVWIDVLLGAGVDVELCRVYELGKTPSAPTKKKKTQGRQVGRGRTSNLQRNSTNPDNGPKPDPESEEEGGSWSSSEDGHGVPQSDGQGADTWEHPNCESRDDHPGTSPPPADTSILGKRDGQMIKLDVHQEVGRTSKRTKANKPIPASTLAQRRSSHRSPKSKIPKDRVRLHTPTPNTTRQRHVPTSISTRGNIKSEPISPKTLGLTGTNIQIGTSSPKIPSFLRLRRYLGKNGSLSQAQSYVRPPPERWLSDPVTPTKRRRETSPASSACVDLEPRSKRKRANSLTDIATCRAPTPSTSSKAAPTDPSPCQADPVEPIITQNRTPRKPAGTLNPKGGVAGSPRDWEKNWPDVFPKWVGDLADQGSDEDYEPSQSQSQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1267-1297Polar residues
Compositional bias1360-1376Basic and acidic residues
Compositional bias1379-1393Polar residues
Compositional bias1527-1545Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP059642
EMBL· GenBank· DDBJ
QRW01531.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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