A0A8H8A345 · A0A8H8A345_9ASCO

Function

function

Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmembrane
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Functioncysteine desulfurase activity
Molecular Functioniron-sulfur cluster binding
Molecular Functionmetal ion binding
Molecular Functionpyridoxal phosphate binding
Biological Process[2Fe-2S] cluster assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    cysteine desulfurase
  • EC number

Gene names

    • ORF names
      PMAC_001454

Organism names

  • Taxonomic identifier
  • Strain
    • P2C
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Pneumocystomycetes > Pneumocystaceae > Pneumocystis

Accessions

  • Primary accession
    A0A8H8A345

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-39Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain145-506Aminotransferase class V

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    542
  • Mass (Da)
    60,919
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    6C493DBFE841F38871DE004D06973BE3
MHLQKFYRLPFKLEGILIERIAVLETLFPFGVGFSTLFGQTMLNGSSRKKASFSIFTGRNLLKKEKKKIRSMLFISGDSIFGNIFLWSNLSILNNTTNRWANLSTITNTFLEKAPEKSTYLLDEAKDPTRSSKNASTRIFGTRPIYLDMQATTPVDPRVLDAMLPYYTYLYGNSHSRTHSYGWETDKAVQIAREHVANLISADPKEIFFTSGATESNNMIIKGVAHFYSGTKKHIITAQTEHKCVLDSCRILQNEGFDVTYLPVNQKGLISLEELERTIRQDTILVSIMTVNNEIGVIQPIEEIGRICRSKKVFFHTDAAQAAGKIPIDVNAFNVDLMSLSGHKIYGPKGVGASYVRRRPRVRVEPLINGGGQERGLRSGTIACPLVIGMGEACRIAKEELEYDYAHVSRLSKKLVERLTQLEYVFFNGDQENRYPGCINASFAYVEGESLLMALKDIALSSGSACTSASLEPSYVIRSLGVPDDISHSSLRFGIGRFTTDKEIDYICDTIKEKINFLRELSPLWEMVQEGVDLSTIKWSYH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABMLO010000015
EMBL· GenBank· DDBJ
KAG5513391.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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