A0A8H8A345 · A0A8H8A345_9ASCO
- Proteincysteine desulfurase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids542 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.
Catalytic activity
- [sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | membrane | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | cysteine desulfurase activity | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | [2Fe-2S] cluster assembly |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecysteine desulfurase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Pneumocystomycetes > Pneumocystaceae > Pneumocystis
Accessions
- Primary accessionA0A8H8A345
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-39 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 145-506 | Aminotransferase class V | |||
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length542
- Mass (Da)60,919
- Last updated2022-01-19 v1
- MD5 Checksum6C493DBFE841F38871DE004D06973BE3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JABMLO010000015 EMBL· GenBank· DDBJ | KAG5513391.1 EMBL· GenBank· DDBJ | Genomic DNA |