A0A8H7S5X2 · A0A8H7S5X2_9FUNG

  • Protein
    Kynureninase
  • Gene
    BNA5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site137pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site138pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site165-168pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site220pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site249pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site252pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site274pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site305pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site333pyridoxal 5'-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionkynureninase activity
Molecular Functionpyridoxal phosphate binding
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processanthranilate metabolic process
Biological ProcessL-kynurenine catabolic process
Biological Processquinolinate biosynthetic process
Biological Processtryptophan catabolic process to kynurenine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kynureninase
  • EC number
  • Alternative names
    • Biosynthesis of nicotinic acid protein 5
    • L-kynurenine hydrolase

Gene names

    • Name
      BNA5
    • ORF names
      INT45_006997

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 142.35
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Lichtheimiaceae > Circinella

Accessions

  • Primary accession
    A0A8H7S5X2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue275N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain114-297Aminotransferase class V

Sequence similarities

Belongs to the kynureninase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    460
  • Mass (Da)
    51,615
  • Last updated
    2022-01-19 v1
  • Checksum
    37584F08D76F3323
MSSSWVIEHFNDLSTTVGKAPHSLELAEHFDKEDSLAKYRNEFAIPIRRNVSGDSPHNASDLDKPSVYLCGNSLGLMPKRSRELVMQELDVWAARGVEGHWDHPHNRPWAPCDENVKDGLAHLVGAKPSEVTAMNTLTANLHAMMAAFYRPTAERYKIVIEAKAFPSDHYAVTSQIHLHGYDPATALVAITPREGEATLRTEDIIDTIRKDDSIALVLLSGIQYYTGQFFDIEKITKAGHEQGCIVGWDLAHAVGNVPLKLHDWQVDFACWCTYKYVNSGPGNIGGLFVHEGHFQDNDRPRLAGWWGNDKKSRFEMAPVFRPSEGAAGYQMSNPSVINIASLLGSLELFQEATIPKLREKSVNLTGYLEYLLITKLEKHIQAGRFKILTPSNPKERGCQLSLDFPEQMITIFDALHARGVVCDERKPTVIRIAPTPLYNTYTDVYYCVSYLDEILNEIFA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEPRB010000064
EMBL· GenBank· DDBJ
KAG2223271.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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