A0A8H7RLG2 · A0A8H7RLG2_9FUNG
- ProteinATP-binding cassette sub-family B member 6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1068 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.heme b (in)CHEBI:60344
+ CHEBI:30616 + CHEBI:15377 = heme b (out)CHEBI:60344+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378 - pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | extracellular region | |
Cellular Component | Golgi membrane | |
Cellular Component | melanosome membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | multivesicular body membrane | |
Cellular Component | vacuolar membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-binding cassette sub-family B member 6
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Mucorineae > Mucoraceae > Mucor
Accessions
- Primary accessionA0A8H7RLG2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endosome membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 132-152 | Helical | ||||
Sequence: LFFTPTILLGFVATVGFFRYL | ||||||
Transmembrane | 173-193 | Helical | ||||
Sequence: LSPLSKLILALSSFVTVTYLV | ||||||
Transmembrane | 213-232 | Helical | ||||
Sequence: FIYYIVTSWIAWVVAIICLL | ||||||
Transmembrane | 244-268 | Helical | ||||
Sequence: LQYTFFAMAAAGESLVAWLWVVSIY | ||||||
Transmembrane | 274-293 | Helical | ||||
Sequence: SIFTIYDNILLGVFLTRYIL | ||||||
Transmembrane | 368-389 | Helical | ||||
Sequence: YLQSLVLACFLLMCLGLTINVF | ||||||
Transmembrane | 409-429 | Helical | ||||
Sequence: AWAAVLAYVGFKFLQGGSGLI | ||||||
Transmembrane | 490-510 | Helical | ||||
Sequence: IVFQIFPALANILIAVIVFSV | ||||||
Transmembrane | 516-535 | Helical | ||||
Sequence: FGLIVFVTMSLYLYTTVTLT | ||||||
Transmembrane | 602-621 | Helical | ||||
Sequence: LAQNAVITGGLLAGSLLFAF | ||||||
Transmembrane | 633-654 | Helical | ||||
Sequence: FVTFNVYMMQLYTPLHFFGTYY |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 374-659 | ABC transmembrane type-1 | ||||
Sequence: LACFLLMCLGLTINVFTPLQIGRVVDKFNQEPETFAWAAVLAYVGFKFLQGGSGLIQAVQNWLWIPIGQYTTREVSVKLFAHLHSLSLHYHINRKTGEVLRTVDRGTNSIVQLLSQIVFQIFPALANILIAVIVFSVRFSLPFGLIVFVTMSLYLYTTVTLTEWRNSFRRKMNELDNFARTKAVDSLLNFETVKYYNAEGFEVDRYDKAIVEYQKADYVNSVSLNVLNLAQNAVITGGLLAGSLLFAFEVSKGNLTPGDFVTFNVYMMQLYTPLHFFGTYYRMIQQ | ||||||
Domain | 693-927 | ABC transporter | ||||
Sequence: VQFDNVTFSYDNRQTALNGISFTIPKGASVALVGPSGGGKSTILRLLFRFYDPDSGCISIDGQDISQVKQSSLRKNIGVVPQDTVLFNDTILYNIRYGDINASDEDVYRAAKAAQIHDKIMSFPDGYETKVGERGLRLSGGEKQRVAIARTILKNPPIILLDEATSALDTTTERHIQVALADMTKGRTTLAIAHRLSTIVNSDLILVVKDGKVVESGSHDDLIQRALSNENEGIY | ||||||
Region | 1020-1068 | Disordered | ||||
Sequence: TPVDNVSPVDNTLLVDNEDDASPSTPTHPSSQSGSKRNRSKKKKRSSRK | ||||||
Compositional bias | 1024-1053 | Polar residues | ||||
Sequence: NVSPVDNTLLVDNEDDASPSTPTHPSSQSG | ||||||
Compositional bias | 1054-1068 | Basic residues | ||||
Sequence: SKRNRSKKKKRSSRK |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,068
- Mass (Da)119,544
- Last updated2022-01-19 v1
- ChecksumA2E0297A93D41B7D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1024-1053 | Polar residues | ||||
Sequence: NVSPVDNTLLVDNEDDASPSTPTHPSSQSG | ||||||
Compositional bias | 1054-1068 | Basic residues | ||||
Sequence: SKRNRSKKKKRSSRK |
Keywords
- Technical term