A0A8H7QEU7 · A0A8H7QEU7_9FUNG

  • Protein
    Cytochrome c oxidase subunit 1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular FunctionDNA binding
Molecular Functionendonuclease activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • ORF names
      INT47_009455

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • WA0000017839
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Mucorineae > Mucoraceae > Mucor

Accessions

  • Primary accession
    A0A8H7QEU7

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane282-308Helical
Transmembrane320-347Helical
Transmembrane367-391Helical
Transmembrane403-427Helical
Transmembrane439-462Helical
Transmembrane474-492Helical
Transmembrane805-824Helical
Transmembrane836-854Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-37
ChainPRO_503493208038-868Cytochrome c oxidase subunit 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-868Cytochrome oxidase subunit I profile
Domain508-596GIY-YIG

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.
To endonucleases of group I introns of fungi and phage.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    868
  • Mass (Da)
    97,654
  • Last updated
    2022-01-19 v1
  • Checksum
    4F8C5C938C635432
MNWFVPLMIGAPDMAFPRLNNISFWLLPPSLILLVASAFVENGAGTGWTVENGKQSPISNNRAIKHHSMRETPLFGKNYSSIVNPLWINDKLAVKMFLTRGQSAWDKLNYSTLSHQRLNVMQPNDEWFLQWLVGMTDGDGSFSILRQGDKLLEDLKSTKPAESYISPAWDGVTLPLADANEAHKVMSKPWLVGFVEAEGSFYLVSKDAKRIVHGFGVTQKLDVVVLEAIRHILHISTKVVFKKKYNHHMIDTTNSRAISNVSEYFLNTMKGIASHSGGSVDLAIFSLHLSGISSMLGAMNFITTIINMRAPGMSFHKMPLFVWAVLITAVLLLLSLPVLAGGITMLLTDRNFNTSFYEPAGGGDPLLYQHLFWFFGHPEVYILIIPGFGIVSHVVSTFCGKPIFGYLGMVYAMLSIGVLGFIVWSHHMYTVGLDVDTRAYFTAATMIIAVPTGIKIFSWLATLYGGSIRFTTPMLFALGFLALFTLGGLTVYSDFKEEKSNILSDNRSKAGIYILYNNATDSYYVGSSSNIARRMSSYFSLAYLNHPKNKNMIICRALLKYDFAPFSLMVVEYCSISNLQEREQYWMDILNPEYNVLKHAFSSQGYKHTPESIKLMSQSAVSRVHSEETKESISKATAKENNPFFGKTHTAETLAQIVLSKSLGLVYLYNEYKELTCIFSSLTSFAKLAESNNNSIKRFIDSQDLFRGNWYISYNLLKDSDTPIIEDHTTDEYKELIQTIIESKYDGVIEAQKALGISHETIKKYCKTAELIKYNYLKVDNFGVMLANASIDVALHDTYYVVAHFHYVLSMGAVFALFSAFYYWIGKITGKTYNELLGQIHFWSLFIGVNLTFFPQHMLGQLKLGLLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEPRD010000467
EMBL· GenBank· DDBJ
KAG2191157.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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