A0A8H7Q0E9 · A0A8H7Q0E9_9FUNG

  • Protein
    Oxidized purine nucleoside triphosphate hydrolase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.56 (UniProtKB | ENZYME | Rhea)
  • 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-ATP + H2O = N6-methyl-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-dATP + H2O = N6-methyl-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Molecular Function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
Molecular Functionmetal ion binding
Biological ProcessDNA protection

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxidized purine nucleoside triphosphate hydrolase
  • EC number
  • Alternative names
    • 2-hydroxy-dATP diphosphatase
    • 7,8-dihydro-8-oxoguanine triphosphatase
    • 8-oxo-dGTPase
    • Methylated purine nucleoside triphosphate hydrolase
    • Nucleoside diphosphate-linked moiety X motif 1

Gene names

    • ORF names
      INT44_006011

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • WA0000051536
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Umbelopsidomycetes > Umbelopsidales > Umbelopsidaceae > Umbelopsis

Accessions

  • Primary accession
    A0A8H7Q0E9

Proteomes

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-133Nudix hydrolase

Sequence similarities

Belongs to the Nudix hydrolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    169
  • Mass (Da)
    19,843
  • Last updated
    2022-01-19 v1
  • Checksum
    52AEEC6215D329C5
MSTITGKKQLTLIFVLDESNKKILLGMKKRGFGHGKFNGFGGKVEKDETILEGAHRELEEEAFVTTPELHRVGLLLFTFENDPKALEVHVFKTNTYNGEPKESEEMRPEWFSYDAIPYDTMWYDDQYWLPIMLQDKHFIGRFDFKEDQTTIINEELKTIDTELPSEWEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEPRA010000007
EMBL· GenBank· DDBJ
KAG2183030.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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