A0A8H7PL34 · A0A8H7PL34_9FUNG
- ProteinEndonuclease III homolog
- GeneNTH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids345 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Catalytic activity
- 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | lyase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | |
Biological Process | base-excision repair, AP site formation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEndonuclease III homolog
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Umbelopsidomycetes > Umbelopsidales > Umbelopsidaceae > Umbelopsis
Accessions
- Primary accessionA0A8H7PL34
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 45-70 | Disordered | ||||
Sequence: HVSESAQVIKHSRPKSTKANKSTNLA | ||||||
Domain | 122-282 | HhH-GPD | ||||
Sequence: LSSQTKDAITAAAMRNLQLKIPGGLTLDNVIACDKDLLHECIKSVGFHTRKTDYIKATAAILKEKYNGDIPDTIEGLISLPGVGPKMGYLTLQCAWDKNIGIGVDVHVHRISNRLGWVKTVNGSPEDTRKACIAYFEALEAWLPKEYWKEINPLLVGFGQI | ||||||
Compositional bias | 322-337 | Basic and acidic residues | ||||
Sequence: LDDKSDTSKKVVKQEE | ||||||
Region | 322-345 | Disordered | ||||
Sequence: LDDKSDTSKKVVKQEEATTDPLSW |
Sequence similarities
Belongs to the Nth/MutY family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length345
- Mass (Da)38,317
- Last updated2022-01-19 v1
- ChecksumD3DDDD1059955D1E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 322-337 | Basic and acidic residues | ||||
Sequence: LDDKSDTSKKVVKQEE |
Keywords
- Technical term