A0A8H7PCU6 · A0A8H7PCU6_MORIS

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      INT43_008277

Organism names

Accessions

  • Primary accession
    A0A8H7PCU6

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane119-139Helical
Transmembrane146-165Helical
Transmembrane209-231Helical
Transmembrane237-262Helical
Transmembrane294-313Helical
Transmembrane333-354Helical
Transmembrane361-383Helical
Transmembrane389-411Helical
Transmembrane453-473Helical
Transmembrane522-544Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region24-63Disordered
Compositional bias34-63Basic and acidic residues
Domain81-476Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    550
  • Mass (Da)
    60,685
  • Last updated
    2022-01-19 v1
  • Checksum
    1D71F413FCEC4AF6
MSESDNETPFRSWHSIRAWSSTYPQMTEPYPTEKPHSSLEESDKERHIPDSEEVKTDVDSKEEKQTDALLATAPWQYKLVALITALMLPIGSHFSQSAISAMKSSIKTKLQINNTRYGVLSSSVSIINTIFPIAGGFFIDAFGSAWGTLAVNAFVIVGCLLTAIAAHIESFALMIVGRVIFGIGSGLIVTMQESLLSKWFRTQHLSIAIGLQLSISRLATFLGTIAAGAIVHDTGNWVWSFWLSFIICAFSVFMNVIYALVVRHLRGQVVTKREVMELKAKKSFNWRSITKFPVYYWHIILIEFIFAAVWSSFQTISTDLVQVHFGTTQVLAAYTASASLVVPIVATPVLGIFMDYFGKRIIILLVSAVFLILSCALLGWTYVNAVVGMVFYSISLAFGPISMITSIGMILPSDYIGTGLGLYKSSNNVGTSILDIVVGVVQDNTAGQAYTGVMILFIVLSCIGFLLIALLWLSQRMYLGNLLEAGHQKRVQKMQEINDQQLLLTKQGEDPYVNVTSGILNYVYIGAFIVCLLVAWVLFFVFAISGQVDV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias34-63Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEPQZ010000020
EMBL· GenBank· DDBJ
KAG2171551.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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