A0A8H7KRI3 · A0A8H7KRI3_9AGAM
- ProteinProton-translocating NAD(P)(+) transhydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1562 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- NAD+ + NADPH + H+(in) = NADH + NADP+ + H+(out)
Cofactor
Note: Binds 2 manganese ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 220-224 | GMP (UniProtKB | ChEBI) | ||||
Sequence: NHFFE | ||||||
Binding site | 221 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 252 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 337 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 337-338 | GMP (UniProtKB | ChEBI) | ||||
Sequence: HN | ||||||
Binding site | 379 | GMP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Active site | 397 | GMP-histidine intermediate | ||||
Sequence: H | ||||||
Binding site | 397-400 | GMP (UniProtKB | ChEBI) | ||||
Sequence: HGAG | ||||||
Binding site | 473 | GMP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | plasma membrane | |
Molecular Function | GTP binding | |
Molecular Function | ligase activity | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity | |
Biological Process | NADPH regeneration | |
Biological Process | proton transmembrane transport | |
Biological Process | RNA processing |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameProton-translocating NAD(P)(+) transhydrogenase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Atheliales > Atheliaceae > Athelia
Accessions
- Primary accessionA0A8H7KRI3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 995-1013 | Helical | ||||
Sequence: FFTFGLAGLVGYRVVWGVA | ||||||
Transmembrane | 1025-1044 | Helical | ||||
Sequence: NALSGMVGIGGLFVLGGGYF | ||||||
Transmembrane | 1051-1070 | Helical | ||||
Sequence: ALGALSVLLASVNVAGGFVI | ||||||
Transmembrane | 1090-1114 | Helical | ||||
Sequence: LYAVPAVVFTGGFLAAASTGMAGLV | ||||||
Transmembrane | 1134-1152 | Helical | ||||
Sequence: LGMLGVGSGVIASLAAVGF | ||||||
Transmembrane | 1158-1175 | Helical | ||||
Sequence: VQFAGLASMGGLIGTVLG | ||||||
Transmembrane | 1187-1208 | Helical | ||||
Sequence: VAALHSVVGLAAVLTSIGSVLA | ||||||
Transmembrane | 1220-1243 | Helical | ||||
Sequence: TAYLGVLIGGITFTGSIVAFLKLA | ||||||
Transmembrane | 1264-1289 | Helical | ||||
Sequence: LGANMLSMAGFLTMAPATVSTAAAFL | ||||||
Transmembrane | 1301-1325 | Helical | ||||
Sequence: YTTTAAVGGADMPVVITVLNAYSGF | ||||||
Transmembrane | 1337-1357 | Helical | ||||
Sequence: SLLTTVGSLIGVSGSVLSYIM |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 569-705 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal | ||||
Sequence: GVPREIYPGERRVALTPTNAALLKKKGVARVLVERGAGTEAQFLDEQYTAAGATLVSREELFASSNVMLKVRPPLIDEEAKHIKEGSTVISFLYPAQNKPIVEALASRKVNSFAMDMIPRISRAQVFDALSSMANIN | ||||||
Domain | 714-878 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding | ||||
Sequence: SNVFGRFLTGQTTAAGKIPPCKVLVIGAGVAGLSAIATARRMGAIVRGFDTRAAAREQVQSLGAEFLEVSIQEDGSGAGGYAKEMSKEFHDAEMALFMAQAKDVDIIITTALIPGKPAPKLITNEMVAAMKPGSVIVDLAAEAGGNVEACRPGIAHVHRGVTVIG |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,562
- Mass (Da)164,933
- Last updated2022-01-19 v1
- ChecksumD8F37753C39419CC
Keywords
- Technical term