A0A8H6Z171 · A0A8H6Z171_9AGAR

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      MVEN_00178700

Organism names

  • Taxonomic identifier
  • Organism
    Mycena venus
  • Strain
    • CCC161011
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Marasmiineae > Mycenaceae > Mycena

Accessions

  • Primary accession
    A0A8H6Z171

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane51-69Helical
Transmembrane89-109Helical
Transmembrane121-142Helical
Transmembrane214-236Helical
Transmembrane274-294Helical
Transmembrane314-334Helical
Transmembrane341-358Helical
Transmembrane440-462Helical
Transmembrane520-539Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-36Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    556
  • Mass (Da)
    60,016
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    8C12CE496EE4733E4E8D4A767790357D
MGSDELPLTPLPVQEKGSFEDKDVSETPKDEVAGLPTSAPTRRKLPLRWKLAIIILTCLCTFGNHWSNGLIVAQKTTIIKTLEINNSEFATLVAVTNLVNTFLCVALGFGIDKWGGPLLSIYLTLFHLAGSAIQAGAVTGHLRSYPVLVLGKVVAAVGDGSLDNAQHRIFSTYFAPGKGFASSIGIIWSIANLAQYTGQTTANVITQNLGSFSWSLWISAVISFFSSVCAIGVFFLDRYLRKTYDITDQTSGLRHVGASKIGVFKLDAIRYMPATFWFIVLFAIFENAGVQSFVSISTQFAQQRLKKGAVVGGWVASMYLLLPVGLTPFIGIFVDLFGHRITLLFMSGLTFLVSMLLLKLSHTVPTFVAAYVMYALSQSITPAPQVEIVRNVLPDPQYFATAFAIKKSVVQASIVIITTAAGKLQDLSATDSLDPAVTLWLSYAAASVAVSGGLLAVSYTTLLPAAHLSQVKPALLDLSIQHLWIKRQAARGADETEDVDPKYQESILKSPVNPRMGWRWVYAGLSVGVVVLGWIMFGLGVNWGVHGSVIAGTTGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACAZI010000002
EMBL· GenBank· DDBJ
KAF7368554.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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