A0A8H6TZH5 · A0A8H6TZH5_9AGAR

  • Protein
    Inosine triphosphate pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10-15ITP (UniProtKB | ChEBI)
Binding site43Mg2+ (UniProtKB | ChEBI)
Binding site55ITP (UniProtKB | ChEBI)
Binding site71Mg2+ (UniProtKB | ChEBI)
Binding site71-72ITP (UniProtKB | ChEBI)
Binding site147-150ITP (UniProtKB | ChEBI)
Binding site170ITP (UniProtKB | ChEBI)
Binding site175-176ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      MVEN_02590500

Organism names

  • Taxonomic identifier
  • Organism
    Mycena venus
  • Strain
    • CCC161011
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Marasmiineae > Mycenaceae > Mycena

Accessions

  • Primary accession
    A0A8H6TZH5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    20,583
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    C3F7FA88E13AB1C0E97590EC051AB716
MAKSNLIFVTGNANKLKEVKAILSAVNSILLRLPCLYVIGVPEIQGTTQEVAIAKCRRAAELLGAPCITEDTALCFEALKGLPGPYIKYFLADLGHEGLNALLVGFPSKAAWALCTFAYSPGPGSDPILFEGRTDGSIVPARGPGIFGWDAVFEPTGTGLTYAEMPTDQKNKLSHRYKALEKLREFLHSLD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACAZI010000039
EMBL· GenBank· DDBJ
KAF7326963.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help