A0A8H6TZH5 · A0A8H6TZH5_9AGAR
- ProteinInosine triphosphate pyrophosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids191 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Catalytic activity
- ITP + H2O = IMP + diphosphate + H+
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10-15 | ITP (UniProtKB | ChEBI) | |||
Binding site | 43 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 55 | ITP (UniProtKB | ChEBI) | |||
Binding site | 71 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 71-72 | ITP (UniProtKB | ChEBI) | |||
Binding site | 147-150 | ITP (UniProtKB | ChEBI) | |||
Binding site | 170 | ITP (UniProtKB | ChEBI) | |||
Binding site | 175-176 | ITP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside triphosphate diphosphatase activity | |
Molecular Function | nucleotide binding | |
Biological Process | deoxyribonucleoside triphosphate catabolic process | |
Biological Process | nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInosine triphosphate pyrophosphatase
- EC number
- Short namesITPase ; Inosine triphosphatase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Marasmiineae > Mycenaceae > Mycena
Accessions
- Primary accessionA0A8H6TZH5
Proteomes
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length191
- Mass (Da)20,583
- Last updated2022-01-19 v1
- MD5 ChecksumC3F7FA88E13AB1C0E97590EC051AB716
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACAZI010000039 EMBL· GenBank· DDBJ | KAF7326963.1 EMBL· GenBank· DDBJ | Genomic DNA |