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A0A8H4WKP0 · A0A8H4WKP0_9EURO

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      HAV15_004436

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • #12
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium

Accessions

  • Primary accession
    A0A8H4WKP0

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane41-60Helical
Transmembrane113-134Helical
Transmembrane206-231Helical
Transmembrane263-284Helical
Transmembrane304-325Helical
Transmembrane332-353Helical
Transmembrane359-377Helical
Transmembrane389-411Helical
Transmembrane431-455Helical
Transmembrane490-511Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-37Disordered
Domain47-454Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    519
  • Mass (Da)
    56,304
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    EB0001E3DF4EAC37B95C6B7D6D05151D
MAVVTSDSKSVDAVSAPVSEDMRTPSEESSDDSDGKSPPPLAAKLIAVALISCISFGSHWSSGVTGAMKSTIKKQMHIDNVQFSLLEASENFMATVLLLISGVITDRVGGAQMIVYGNIVYTIGSILVAAAATVRSFDFMIGGRVILALGDIATQIAQYKMFSSWFPPSSGFASTLGFELAIGKIGGFVGKATANIIAKKTGNFAWVFWTSVFMNLFTNVASAGFWFFNIYCNRHYKGRRDTATKEQLTEKNQKFEFQKLFELPWMFWAVMAFSIFQTSAASVFSQNATELAEKRFNVDSIKAGWYSSLSQYAGFFLVPCLGVFIDILGNRASVLFVCGLGMLLSMVLINFATSHAGTGAAFGIYAIAVSLGPTSVIDSIRTSLWHQSVFGSAYALKVTMNNAMSIIIRIITGALQDADDNSYRRVVQVYLVLAAGALVVGAAILIGSFLTDNLAPLQWTRHKRLTSGAVIIERIREHNLVTMYQRTRKISIICFGALILLTLGSWVAYIWGAVTGHNS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAASRZ010000041
EMBL· GenBank· DDBJ
KAF4771547.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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