A0A8H4UCR9 · A0A8H4UCR9_9HYPO

Function

function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological ProcessDNA topological change
Biological Processresolution of meiotic recombination intermediates
Biological Processsister chromatid segregation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 2
  • EC number

Gene names

    • ORF names
      FZEAL_9246

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NRRL 22465
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium staphyleae species complex

Accessions

  • Primary accession
    A0A8H4UCR9

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias50-66Polar residues
Region50-159Disordered
Compositional bias141-158Basic and acidic residues
Domain590-708Toprim
Region1224-1248Disordered
Region1331-1366Disordered
Compositional bias1338-1358Basic and acidic residues
Compositional bias1386-1400Basic and acidic residues
Region1386-1709Disordered
Compositional bias1432-1451Basic and acidic residues
Compositional bias1488-1508Polar residues
Compositional bias1592-1606Basic and acidic residues
Compositional bias1690-1709Acidic residues

Sequence similarities

Belongs to the type II topoisomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,709
  • Mass (Da)
    191,107
  • Last updated
    2022-01-19 v1
  • Checksum
    1B005A2C62B11252
MDSDESMFSLADESDGFVPEVVSDSLGSPSHLSTPLNFAYSCITTTNIPLMNPRPRLTSPTQKTKPNPAVKKAAARPAVKKMAQTTLKAKPGAKKRSTPESDDENVTDASGFSNTPPKSKKQKKDTLPSKSPGVSLAELDDDSMADDKPDKPKTKKTATETYQKLTQLEHILKRPDTYIGSVERTEQQMWVFNKETALMEYRKVFFVPGLYKIFDEILVNAADNKQRDGAMTYMKINIDRVNGVISVENNGKGIPIVIHEKEKIYIPELLFGHLLAGSNFDDNEKKTVGGRNGYGAKLCNVFSTEFNLECQDSEHGKRYKQTWTDNMQKMQKAKITSSKTSDFTRITFKPDFKRFGMEEGIDDDLESLLYRRVYDMVGTVRGIKVHLNGEQIKVKDFKAYCDLYAKSIAKERSMEEGGAPTCTVEMDKEKGHPLWEVGFAVSDGNFQQVSFVNSIATTSGGTHVNYIADQITSHLLATLNKRKKGHPLKQSHLRNHIFIFVNCYVNNPAFTSQTKEQMTTKASQFGSKCKLGEEFLKKVAKSEALQNIMEFAERKADKAMSKSDGNKRSRVSNAKLVEANLAGTRHGHLCTLILTEGDSAKGLAVSGRAILDPDKIGVFPLRGKMLNVRDANLDQITKNQEIQNIKQILGLKHKHVYTDTKGLRYGHLMIMADQDHDGSHIKGLLINFLQVQFPSLLLVPEFFREFITPIVKVWQGPNPKKPLRLKSFFTQPEYEDWKETHQNELTRWHSKYFKGLGTSSNEDAQVYFTNLDDHLKEFEVMKPQEAELFELAFSKKKADARKEWLGNFLPGTYLDHSTKSISYTNFVNRELILFSMADNMRSIPSVLDGFKPGQRKVLYACFKRNLIKDKKVVELAGYISEQTAYHHGEQSLQQTIIGLAQNFVGSNNINCLEPSGNFGSRLAGGSDAASPRYTFTRLSPFARKIFSPMDEPNLEHQDDDGKKIEPVAYAPIIPMVLVNGADGIGTGWSTSIPNYHPADIVKNLRRRMGRLDEDDSEEKPFVTMTPWFRGWKGEPEPAGPDRYKFNGLAHQNEQNPNEIIITELPIRMWTDDFKAKLEKVISGVDGPSWIKDYKEFNDHSTVHFEIVVDEKHTGKVIDEGIHERFKLNKQVATSNLVGFDSRGQIRKYEKVEDILEEYYHYRLDMYIKRKKHWLSVYHADYRKLKNQARFIKEIIDGDLIVGKKKKAVLVQELRDRNYEAFPRGGDKKKTADEDDEAEDDQDVEGDMDSGARDYDYLLSMPIWSLTAERLEKLKLAIEKKKAEHDELLALSEKDLWCRDLDDFMVEWNNQLALDAEIKTSIRRLGRRASKKIGAGNARARKPKADDEYEPEKKGRGRPKAAAATKPAIKAAVIAETNAAQRFTEKFSAKPKVKKESSADAMEISDNFSDDDYAALSRSKPTAKPAQQSPEEPDTGRVKRAAASRARAIFDDESESDDDQMLGDVGALVKGIDKPAGNSGRGRFSLHAMSRPDSSQGNNSVNGLPKTKPKSAKSFNFDDDSPDDTNYELLAQSSPHKTAAKDDHIDSFLSDDEPFVAPSKTAAAAKSKSASSEEPAVPAGLSAVKKPRGRPAATKSKAKEDAKPKAAPKTSKAAPKAATKVAARPATKQTTLSPAAKAYAAKRAAKKSVLEDDSDEDMAEPESPPPKAAPRGRPGRAAAARRPVVIDDDSSAVQPDEESDDPFEMDDDED

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias50-66Polar residues
Compositional bias141-158Basic and acidic residues
Compositional bias1338-1358Basic and acidic residues
Compositional bias1386-1400Basic and acidic residues
Compositional bias1432-1451Basic and acidic residues
Compositional bias1488-1508Polar residues
Compositional bias1592-1606Basic and acidic residues
Compositional bias1690-1709Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABEYC010000841
EMBL· GenBank· DDBJ
KAF4973719.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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