A0A8H4UCR9 · A0A8H4UCR9_9HYPO
- ProteinDNA topoisomerase 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1709 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA topological change | |
Biological Process | resolution of meiotic recombination intermediates | |
Biological Process | sister chromatid segregation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium staphyleae species complex
Accessions
- Primary accessionA0A8H4UCR9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 50-66 | Polar residues | |||
Region | 50-159 | Disordered | |||
Compositional bias | 141-158 | Basic and acidic residues | |||
Domain | 590-708 | Toprim | |||
Region | 1224-1248 | Disordered | |||
Region | 1331-1366 | Disordered | |||
Compositional bias | 1338-1358 | Basic and acidic residues | |||
Compositional bias | 1386-1400 | Basic and acidic residues | |||
Region | 1386-1709 | Disordered | |||
Compositional bias | 1432-1451 | Basic and acidic residues | |||
Compositional bias | 1488-1508 | Polar residues | |||
Compositional bias | 1592-1606 | Basic and acidic residues | |||
Compositional bias | 1690-1709 | Acidic residues | |||
Sequence similarities
Belongs to the type II topoisomerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,709
- Mass (Da)191,107
- Last updated2022-01-19 v1
- Checksum1B005A2C62B11252
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 50-66 | Polar residues | |||
Compositional bias | 141-158 | Basic and acidic residues | |||
Compositional bias | 1338-1358 | Basic and acidic residues | |||
Compositional bias | 1386-1400 | Basic and acidic residues | |||
Compositional bias | 1432-1451 | Basic and acidic residues | |||
Compositional bias | 1488-1508 | Polar residues | |||
Compositional bias | 1592-1606 | Basic and acidic residues | |||
Compositional bias | 1690-1709 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JABEYC010000841 EMBL· GenBank· DDBJ | KAF4973719.1 EMBL· GenBank· DDBJ | Genomic DNA |