A0A8H4T2S0 · A0A8H4T2S0_9HYPO
- ProteintRNA (guanine-N(7)-)-methyltransferase
- GeneTRM8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1490 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.
Catalytic activity
- guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine
Pathway
tRNA modification; N7-methylguanine-tRNA biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 90 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 113-114 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 147-148 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 167 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 170 | ||||
Binding site | 245-247 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | nucleus | |
Molecular Function | phosphatidylinositol binding | |
Molecular Function | tRNA (guanine(46)-N7)-methyltransferase activity | |
Molecular Function | tRNA binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA (guanine-N(7)-)-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium nisikadoi species complex
Accessions
- Primary accessionA0A8H4T2S0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 265-282 | Helical | |||
Transmembrane | 288-311 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Forms a complex with TRM82.
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-28 | Disordered | |||
Domain | 355-544 | PXA | |||
Region | 559-578 | Disordered | |||
Region | 644-669 | Disordered | |||
Domain | 671-809 | RGS | |||
Compositional bias | 821-846 | Polar residues | |||
Region | 821-932 | Disordered | |||
Compositional bias | 857-886 | Polar residues | |||
Compositional bias | 918-932 | Polar residues | |||
Region | 1033-1057 | Disordered | |||
Domain | 1139-1257 | PX | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Belongs to the sorting nexin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,490
- Mass (Da)167,255
- Last updated2022-01-19 v1
- MD5 Checksum92D1A3D2A0BEE07314089265A9AF5441
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 821-846 | Polar residues | |||
Compositional bias | 857-886 | Polar residues | |||
Compositional bias | 918-932 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JABFAI010000218 EMBL· GenBank· DDBJ | KAF4950187.1 EMBL· GenBank· DDBJ | Genomic DNA |