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A0A8H4T2S0 · A0A8H4T2S0_9HYPO

  • Protein
    tRNA (guanine-N(7)-)-methyltransferase
  • Gene
    TRM8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

tRNA modification; N7-methylguanine-tRNA biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site90S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site113-114S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site147-148S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site167S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site170
Binding site245-247S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Functionphosphatidylinositol binding
Molecular FunctiontRNA (guanine(46)-N7)-methyltransferase activity
Molecular FunctiontRNA binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA (guanine-N(7)-)-methyltransferase
  • EC number
  • Alternative names
    • Transfer RNA methyltransferase 8
    • tRNA (guanine(46)-N(7))-methyltransferase
    • tRNA(m7G46)-methyltransferase

Gene names

    • Name
      TRM8
    • ORF names
      FGADI_8335

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NRRL 45417
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium nisikadoi species complex

Accessions

  • Primary accession
    A0A8H4T2S0

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane265-282Helical
Transmembrane288-311Helical

Keywords

Interaction

Subunit

Forms a complex with TRM82.

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-28Disordered
Domain355-544PXA
Region559-578Disordered
Region644-669Disordered
Domain671-809RGS
Compositional bias821-846Polar residues
Region821-932Disordered
Compositional bias857-886Polar residues
Compositional bias918-932Polar residues
Region1033-1057Disordered
Domain1139-1257PX

Sequence similarities

Belongs to the sorting nexin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,490
  • Mass (Da)
    167,255
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    92D1A3D2A0BEE07314089265A9AF5441
MTTELTNKQKEREKDRAKRTKDGVTQLPRKKFYRQRAHANPFSDHMLEYPKSPDDMDWSSYFPHYVQEGTPEDPSKPPKLTKDVEIVDIGCGFGGLLVALAPKLPDTLTLGLEIRTQVAGYVQERIKALRSRNSDNLYQNVGCIRANTMKFLPNFFKKAQLSKIFICFPDPHFKARKHKARIVSTTLNSEYAYALRPGGIVYTITDVEDLHLWMVQHLEAHPAFERISKEEEEADECVQVMSTETEEKCGSEVNILVMALKRRDVIVAGLAAFIAWGFAASWSPVLRWAGHAFVAGSLVTLVALLAGLFLVSRRPSDRILRPHGVTFLNKNSWRSEVQGLRQRQSYTPTPIDPESPRVSEAIDHLLGLVNRDFVNSWYSNISRNPSFSNQVDHAVRQALLSLTDFLRHKDLAELVTSRLVPLLTAHFRDFYEAEKSVRGKKLNRSVTESEELDLAIASKFRDGRLHPAASLSFPDTKMVQQDYLRSLVAKIVPKILPDNMLSSRAVSIIIREIVACAVLFPVIQLLSEPDTWNQLMENLGRSMLQDRSTVRKLRAALDQHAPSTPKASKLASMPRVAPGDSERKFEKFIRAIRKVNNLSDARRFRSEVASQLKRDSVEDNQDQVYLRRLEMGKRLLDQRVNHLAAGGERRPPGPLPLPSTSSSQSKLESAPLVDILRDSSALSYFMEYMDRQNLMPLVQFWLVVDGFRNPLEDDGPDDELPSTLPMWTDADRQDLQQINQAYLSRPELKVPDHSRNEVKEFIKAGKSATPLQYYRARRAILKAQSAVLEEMRSRFFQSFKKSDLFYKCLAAEEAANIQTLRSTPQPEVQAQAQAQATASATNRASKSLPAKPRPVSRLTPQLSNAGKRTGSASDLKSLTSNGNGHGHRARRSLDEGSFNPLFDDDDIDTDGLGDSVQSLDPDANSQQLPDTQVVKAVEQAFTDIMEDDRPQTAEALRASLFGGPGGSSIGGIDDNASSLFSGNDNESHRGSLDMGIRPAMANKEGEKPSLSSLGLVSAASRIGVFVDDDLFGDNNKDLPDDGDPDDGPPADDEDEVHEAAPGDLGLAEAITALSNDIDRLVAQEAVVDSLTRKAELTNNTAELRILRKSKASLHREIRRKELQRQQYVIQESDNSLYGRSTIKIKSIQVGREEDGREFALYVIEVQRNAGEQMPAASWVISRRYSEFHELHQKLRSRYPSVRNLDFPRRRMVMKFQSEFLRKRRTALEQYLQDLLLLPEVCRSRELRAFLSQSVIAQGQDILDREDKKDMMTRLYDSVADGMDDILGNIPVLDQISEAGQNLIAAATNQLNAVPLNVNEDTFPAAEAEAELNAFENKELEPFIKPICDIFLEIFELNKGNNWLRGRAVVVVLQQLLGGTIERKVRDNVKMLVQDENILKYIGLVQDSLWPGGQLQRDRKPRTAAEKKKTRTEASLMLATLVPDLAGSVVGRVNAQTASRRIFATLNNSRLNAHLVFTMIDEIVSVLFEEP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias821-846Polar residues
Compositional bias857-886Polar residues
Compositional bias918-932Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABFAI010000218
EMBL· GenBank· DDBJ
KAF4950187.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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