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A0A8H4S0D7 · A0A8H4S0D7_9EURO

  • Protein
    GTP:AMP phosphotransferase, mitochondrial
  • Gene
    ADK2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

125520406080100120140160180200220240
TypeIDPosition(s)Description
Binding site21-26GTP (UniProtKB | ChEBI)
Binding site43AMP (UniProtKB | ChEBI)
Binding site48AMP (UniProtKB | ChEBI)
Binding site69-71AMP (UniProtKB | ChEBI)
Binding site129-132AMP (UniProtKB | ChEBI)
Binding site136AMP (UniProtKB | ChEBI)
Binding site166GTP (UniProtKB | ChEBI)
Binding site175-176GTP (UniProtKB | ChEBI)
Binding site199AMP (UniProtKB | ChEBI)
Binding site210AMP (UniProtKB | ChEBI)
Binding site239GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular Functionnucleoside triphosphate adenylate kinase activity
Biological ProcessADP biosynthetic process
Biological ProcessAMP metabolic process
Biological ProcessGTP metabolic process
Biological ProcessITP metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP:AMP phosphotransferase, mitochondrial
  • EC number
  • Alternative names
    • Adenylate kinase 3
      (AK 3
      )

Gene names

    • Name
      ADK2
    • ORF names
      HAV15_007634

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • #12
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium

Accessions

  • Primary accession
    A0A8H4S0D7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region42-71NMPbind
Region91-117Disordered
Compositional bias92-117Polar residues
Region165-202LID
Domain166-201Adenylate kinase active site lid
Region178-198Disordered
Compositional bias183-198Basic and acidic residues

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. AK3 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    255
  • Mass (Da)
    28,014
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    3DD60A0BAE418CEC6CC75CB08A852207
MSHVTKQLRKAARIILIGAPGVGKGTQSERLLARFPQLASISSGDLLRENVRRRTPLGLEAEATMQSGNLVPDSMILNLISDDMKSKGWLLPPSASSVQSATSSSSSSPADTSSSAHSIDSSASFILDGFPRTAIQATTLDSLVPVNFVVHLITPPSVILARIASRWVHEPSGRVYNTDFHPPKVAGKDDVTGEPLTQREDDSLDTWKQRLRKFEETSKSLLEHYDRQRCLFRAEGNSSDEISPKLFAEIERRFC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias92-117Polar residues
Compositional bias183-198Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAASRZ010000051
EMBL· GenBank· DDBJ
KAF4760271.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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