A0A8H4PUP6 · A0A8H4PUP6_9HYPO
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids168 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = diphosphate + dUMP + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Ophiocordycipitaceae > Ophiocordyceps
Accessions
- Primary accessionA0A8H4PUP6
Proteomes
Interaction
Subunit
Homotrimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-26 | Polar residues | ||||
Sequence: MSAADPSSPPNKRIKTTDQGSSNMEP | ||||||
Region | 1-27 | Disordered | ||||
Sequence: MSAADPSSPPNKRIKTTDQGSSNMEPA | ||||||
Domain | 38-166 | dUTPase-like | ||||
Sequence: KGRLPTRGSAFAAGYDLYAAKDTTVPARGKVLVDTDISIAVPAGTYGRIAPRSGLASKHFIDTGAGVIDADYRGQVKVLLFNHADADFDIKEGDRVAQLVLERIVTPDVVEVQELEESVRGAGGFGSTG |
Sequence similarities
Belongs to the dUTPase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length168
- Mass (Da)17,740
- Last updated2022-01-19 v1
- Checksum54EA15DD25BD2BEB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-26 | Polar residues | ||||
Sequence: MSAADPSSPPNKRIKTTDQGSSNMEP |
Keywords
- Technical term