A0A8H3WYI2 · A0A8H3WYI2_GIGMA

  • Protein
    Adenylosuccinate synthetase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site23-29GTP (UniProtKB | ChEBI)
Active site24Proton acceptor
Binding site24Mg2+ (UniProtKB | ChEBI)
Binding site24-27IMP (UniProtKB | ChEBI)
Binding site49-52IMP (UniProtKB | ChEBI)
Binding site51Mg2+ (UniProtKB | ChEBI)
Binding site51-53GTP (UniProtKB | ChEBI)
Active site52Proton donor
Binding site140IMP (UniProtKB | ChEBI)
Active site151
Binding site154IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site231IMP (UniProtKB | ChEBI)
Binding site246IMP (UniProtKB | ChEBI)
Binding site306-312substrate
Binding site310IMP (UniProtKB | ChEBI)
Binding site312GTP (UniProtKB | ChEBI)
Binding site338-340GTP (UniProtKB | ChEBI)
Binding site420-422GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      F8M41_012758

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BEG34
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Glomeromycotina > Glomeromycetes > Diversisporales > Gigasporaceae > Gigaspora

Accessions

  • Primary accession
    A0A8H3WYI2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    47,934
  • Last updated
    2022-01-19 v1
  • Checksum
    4D9130A8396C30BF
MGLFTTSNISDVGVTVVLGSQWGDEGKGKLVDLLAQEADICARCAGGNNAGHTIVVNGTKYDFHLLPSGLINPNCISIVGSGVVVHLPSFFEELKTLEGKGLNTSGRLFISDRAHLVFDFHQIVDGLKEKELGQSSIGTTKKGIGPAYSSKASRSGLRVHHLSNHEAFAEKFRKLVENRKKRYGHFEYDVEAEIERYKHFAIRLKPYVVDSVSFMHKSLTLRKKVLVEGANALMLDLDFGTYPYVTSSNTTIGGVSTGLGIPPSKIDKVIGVMKAYTTRVGGGPFPTELNDEKGEYLQRVGAEYGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNLTKLDVLDNLNELKVATAYCIDGKPLESFPADLDVLEKVTVQYEILKGWKSDISKCRRFSELPENAQKYVKFIENYLGVPIEWIGVGVNREDMIDLKKA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WTPW01002596
EMBL· GenBank· DDBJ
KAF0375434.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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