A0A8H3EFZ3 · A0A8H3EFZ3_9LECA

  • Protein
    5-aminolevulinate synthase
  • Gene
    HEM1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular Function5-aminolevulinate synthase activity
Molecular Functionpyridoxal phosphate binding
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-aminolevulinate synthase
  • EC number
  • Alternative names
    • 5-aminolevulinic acid synthase
    • Delta-ALA synthase
    • Delta-aminolevulinate synthase

Gene names

    • Name
      HEM1
    • ORF names
      IMSHALPRED_000087

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Lecanoromycetes > OSLEUM clade > Lecanoromycetidae > Lecanorales > Lecanorineae > Parmeliaceae > Imshaugia

Accessions

  • Primary accession
    A0A8H3EFZ3

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region110-130Disordered
Domain181-533Aminotransferase class I/classII

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    614
  • Mass (Da)
    66,425
  • Last updated
    2022-01-19 v1
  • Checksum
    2C63E9E5D25B2552
METLLRQSRSMCPFLNKTSPATLRSLSTTTRHVSPGGGTMSNLQVLARRCPVMGKAMNAQAAKSGTNLLNGVFGGVRAYGGKAKMHTSRPQKASVASDLLGDESHVPIHHTQKRKTQAQQAAATSGPKPAAPKLATFDYEGFYNTELDKKHKDKSYRYFNNINRLAQEFPQAHMTARDERVTVWCSNDYLGMGRNPQVLKAMHETLDTYGSGAGGTRNISGHNQHAVALESTIARLHAQEAALVFSSCYVANDATLATLGSKLPNCVILSDSMNHASMIQGIRHSGAKKLVFKHNNLADLEAKLASLPPDVPKIIAFESVYSMCGSIGPIEEICDLADKYGAITFLDEVHAVGMYGPHGAGVAEHLDYEAHVAGRPKGTIMDRIDIITGTLGKAYGCVGGYIAGSAKMVDTIRSLAPGFIFTTSLPPATMAGAKTAIEYQMEFQGDRRLQQLHTRSTKQALVEKGLPVMPNPSHIIPVLVGNAELAKQASDLLLKDWGIYVQAINYPTVPVGEERLRFTPTPGHVEKYQKELVIALDAVWNQLDIKRTADWAKQGGFVGVGVDAEEVEPLWTDEQLGLHDRAEKAGLRVLEEEKAIQGSIDEMGELPHAVAAAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJPDT010000001
EMBL· GenBank· DDBJ
CAF9904503.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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