A0A8G0VV66 · A0A8G0VV66_9PAPI

Function

function

Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentT=7 icosahedral viral capsid
Molecular Functionstructural molecule activity
Biological Processsymbiont entry into host cell
Biological Processvirion attachment to host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Major capsid protein L1

Gene names

    • Name
      L1

Organism names

  • Taxonomic identifier
  • Strain
    • C45
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae

Accessions

  • Primary accession
    A0A8G0VV66

Proteomes

Subcellular Location

Keywords

Expression

Keywords

Interaction

Subunit

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region543-580Disordered
Compositional bias547-561Polar residues

Sequence similarities

Belongs to the papillomaviridae L1 protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    580
  • Mass (Da)
    64,959
  • Last updated
    2022-01-19 v1
  • Checksum
    002768F5EBEEB7BC
MLEMIILLIGLNILLIRNVRRKKIVLILVFQMLRGRHNNKVVVRPNVFEGGVPVSPVMRSTDEFTHDTGLVYAVTSQLMSLIGHPHYDITKSRKRRGKTVTDVILPMVSPFQFRVFELNLPDPNHMSFPETLEHRNLSSQRYVWSVEMVEVTRNGPLGVPLTGNSMFAKFADIENPVVDWTKREKQKGAKGGVDNKDGRVMVGFDGKQTQFIAIGAKPLKGFSWTGTESGVKGGCPILTRVVEDIKDGDLGDIGFGNIDPATLCLDEWHLPIEMKDRKCVSPDIDNMLKDGMGDCMFMYINREQLFAKHFWDMAGNGGEVTEDMTKPLEGKVIPSGSLAASAQSIFGKPYWLNQSVGPNNGLLWDNKLYVTCMDTTHGASFNIVVPKPQTAGDGDQLQQAAGSDNHFSSAKPCEEFNPLSSEYDSARNADAYDPSKWNEFQRHVSEWSVEAIVRLKTITLEGELMLLLDQKYPDLLNNWGFGWKENSELTPYQTNMITSQQSMRRCPEENVLGADEEQEVQSNIVIDSNGDCKLEMHDELHRTPLGRKYQNLQTSGKVQPAKKSSPPKGGIKKTPAKRKK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias547-561Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MZ570859
EMBL· GenBank· DDBJ
QYW06007.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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