A0A8G0LST3 · A0A8G0LST3_9HYPO
- ProteinGlutathione hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids572 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 108 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 382 | Nucleophile | ||||
Sequence: T | ||||||
Binding site | 400-402 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: TIN | ||||||
Binding site | 424 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 452-453 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: SS | ||||||
Binding site | 475 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | acyltransferase activity | |
Molecular Function | glutathione hydrolase activity | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Hypocreaceae > Trichoderma
Accessions
- Primary accessionA0A8G0LST3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MTQLRLRSAMKPLILLLSVLPYSKA | ||||||
Chain | PRO_5034888877 | 26-572 | Glutathione hydrolase | |||
Sequence: SPTPPCSTPPGVHIPKQGAVASQSTVCSEIGIQLLKDGGNAVDALVGTVFCVGVIGMYHSGIGGGGFLLLRTSDGKYEFVDLRETAPAAATQDMYNDDENLSIYSGLASGVPGELRGTEYIHNKYGALPWAHVIKPSIEVARNGFKVTEDLISTIKSTSPNNFLTEDPAWAIDFAPKGRLVRLGETMTRKRYADTLESIARHGADAFYTGPIANATIRALKAAGGIMTLEDLKNYTVAIREPLQINYRGYKLTSTSAPSSGAVVLSALNTVSGYENFGHPDQVNLTTHRLDEAIRFAYGQRTELGDPSFVEGLDKYSKEMIAPATGAEIRSKISDFKTQNVSYYDPKGLESLETPGTSHIVAADASGMAVSMTTTINLLFGSTLIVPETGVIMNNEMNDFSIPGVSNSFGYIPSPANYIRPGKRPLSSISPIIAETADGKLYLALGAAGGSRIITANIQNTIHVLDSNMTTAEALASPRLHDQLVPDQTSFEYAYDNRTVAFMKSLGHNVTWVAPGQSAAQAVRLLPNGTFEAAGEPRQVTSGGFAI |
Structure
Sequence
- Sequence statusComplete
- Length572
- Mass (Da)61,106
- Last updated2022-01-19 v1
- Checksum564B364C8819FB90