A0A8F4TKW9 · A0A8F4TKW9_9MUSC
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids578 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA0A8F4TKW9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-30 | Helical | ||||
Sequence: VNLISISLSCFLLSLYFLL | ||||||
Transmembrane | 50-75 | Helical | ||||
Sequence: VMTFLFDWMSLLFMSFVLMISSLVIF | ||||||
Transmembrane | 87-106 | Helical | ||||
Sequence: INRFIMLVLMFVLSMMLLII | ||||||
Transmembrane | 112-131 | Helical | ||||
Sequence: SILLGWDGLGLVSYCLVIYF | ||||||
Transmembrane | 152-170 | Helical | ||||
Sequence: VAFLLAIAWMLNYGSWNYI | ||||||
Transmembrane | 182-206 | Helical | ||||
Sequence: MLVIGSLVMLAAMTKSAQIPFSSWL | ||||||
Transmembrane | 218-238 | Helical | ||||
Sequence: ALVHSSTLVTAGVYLLIRFNI | ||||||
Transmembrane | 244-266 | Helical | ||||
Sequence: WLGQLLLLLSGLTMFMAGLGANF | ||||||
Transmembrane | 273-293 | Helical | ||||
Sequence: IIALSTLSQLGLMMSILSMGF | ||||||
Transmembrane | 299-319 | Helical | ||||
Sequence: FHLLTHALFKALLFMCAGAII | ||||||
Transmembrane | 340-361 | Helical | ||||
Sequence: LTSACFNVSNLALCGMPFLAGF | ||||||
Transmembrane | 381-400 | Helical | ||||
Sequence: FFLYFFSTGLTVSYSFRLVY | ||||||
Transmembrane | 421-444 | Helical | ||||
Sequence: VMLRGMLGLLIMSIIGGSMLNWLI | ||||||
Transmembrane | 456-475 | Helical | ||||
Sequence: YMKLLTLFVCISGGLFGYLI | ||||||
Transmembrane | 487-505 | Helical | ||||
Sequence: LLNYSISVFLGSMWFMPYI | ||||||
Transmembrane | 559-577 | Helical | ||||
Sequence: IYLMLFVFWILILFNFLLF |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-90 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | ||||
Sequence: VSLNSMSIVMTFLFDWMSLLFMSFVLMISSLVIFYSKEYMESDENINRF | ||||||
Domain | 107-390 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: SPNLISILLGWDGLGLVSYCLVIYFQNVKSYNAGMLTALSNRIGDVAFLLAIAWMLNYGSWNYIFYLEVMQNEVEMLVIGSLVMLAAMTKSAQIPFSSWLPAAMAAPTPVSALVHSSTLVTAGVYLLIRFNIILSTSWLGQLLLLLSGLTMFMAGLGANFEFDLKKIIALSTLSQLGLMMSILSMGFYKLAMFHLLTHALFKALLFMCAGAIIHNMNNSQDIRLMGGLSIHMPLTSACFNVSNLALCGMPFLAGFYSKDMILEIVMISNINLFSFFLYFFSTGL | ||||||
Domain | 394-573 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSFRLVYYSMTGDLNCGSLNMLNDESWVMLRGMLGLLIMSIIGGSMLNWLIFPIPYMICLPLYMKLLTLFVCISGGLFGYLISMTKIYSLNKSLLNYSISVFLGSMWFMPYISTYGMIFYPLSYGQLVVKSFDQGWSEYFGGQHLYQKLVTYSQTLFLMHNNSLKIYLMLFVFWILILFN |
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length578
- Mass (Da)65,630
- Last updated2022-01-19 v1
- ChecksumDBBDFA339B2A40E2