A0A8F0ZWG1 · A0A8F0ZWG1_9BETC

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site6000
Active site6002
Active site6101
Active site6178
Active site6183
Binding site6241-6247S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site6671
Active site6686
Active site6726

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum-Golgi intermediate compartment
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular Function3'-5'-RNA exonuclease activity
Molecular Function5'-3' DNA helicase activity
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionendonuclease activity
Molecular FunctionG-quadruplex RNA binding
Molecular Functionlyase activity
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionomega peptidase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionsingle-stranded RNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription
Biological Processinduction by virus of host autophagy
Biological Processproteolysis
Biological Processsymbiont-mediated degradation of host mRNA
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host ISG15-protein conjugation
Biological Processsymbiont-mediated suppression of host NF-kappaB cascade
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral protein processing
Biological Processviral RNA genome replication
Biological Processviral translational frameshifting
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ORF1ab polyprotein

Gene names

    • Name
      ORF1ab

Organism names

  • Taxonomic identifier
  • Strain
    • Bat/Yunnan/RmYN08/2020
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Sarbecovirus

Accessions

  • Primary accession
    A0A8F0ZWG1

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane2211-2231Helical
Transmembrane2356-2379Helical
Transmembrane2754-2775Helical
Transmembrane3028-3050Helical
Transmembrane3062-3086Helical
Transmembrane3093-3115Helical
Transmembrane3121-3142Helical
Transmembrane3567-3590Helical
Transmembrane3596-3614Helical
Transmembrane3621-3642Helical
Transmembrane3668-3686Helical
Transmembrane3716-3740Helical
Transmembrane3752-3774Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond2267↔2273

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain12-127CoV Nsp1 globular
Domain148-179BetaCoV Nsp1 C-terminal
Domain183-456CoV Nsp2 N-terminal
Domain458-688CoV Nsp2 middle
Domain690-818CoV Nsp2 C-terminal
Domain821-929Ubiquitin-like
Domain1012-1178Macro
Domain1215-1343Macro
Domain1351-1478Macro
Domain1480-1552DPUP
Domain1550-1605Ubiquitin-like
Domain1619-1883Peptidase C16
Domain1896-2006Nucleic acid-binding
Domain2031-2140G2M
Domain2232-23023Ecto
Region2380-2470Y1
Domain2380-2748CoV Nsp3 Y
Region2384-2397ZF1
Region2430-2440ZF2
Region2471-2565Y2
Region2471-2748CoV-Y
Region2566-2647Y3
Region2648-2748Y4
Domain3150-3248Nsp4C
Domain3249-3554Peptidase C30
Domain3845-3927RdRp Nsp7 cofactor
Domain3928-4125RdRp Nsp8 cofactor
Domain4126-4238Nsp9 ssRNA-binding
Domain4239-4377ExoN/MTase coactivator
Domain4384-4638NiRAN
Domain4643-4741Nsp12 Interface
Domain4742-5309Nsp12 RNA-dependent RNA polymerase
Domain4989-5151RdRp catalytic
Domain5310-5393CV ZBD
Domain5566-5917+RNA virus helicase C-terminal
Domain5982-6197ExoN
Domain6206-6437N7-MTase
Region6324-6338GpppA-binding
Domain6438-6498Nsp15 N-terminal oligomerization
Domain6499-6624AV-Nsp11N/CoV-Nsp15M
Domain6641-6780NendoU
Domain6785-7079Nidovirus-type SAM-dependent 2'-O-MTase

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    7,081
  • Mass (Da)
    791,648
  • Last updated
    2022-01-19 v1
  • Checksum
    CAC716B8946C4170

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MZ081378
EMBL· GenBank· DDBJ
QWN56221.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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