A0A8E5JLA7 · A0A8E5JLA7_SALEN

Function

function

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site36

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionacyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
Molecular FunctionATP binding
Molecular Functionlong-chain fatty acid [acyl-carrier-protein] ligase activity
Biological Processfatty acid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein Aas

Including 2 domains:

  • Recommended name
    2-acylglycerophosphoethanolamine acyltransferase
  • EC number
  • Alternative names
    • 2-acyl-GPE acyltransferase
    • Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase
  • Recommended name
    Acyl-[acyl-carrier-protein] synthetase
  • EC number
  • Alternative names
    • Acyl-ACP synthetase
    • Long-chain-fatty-acid--[acyl-carrier-protein] ligase

Gene names

    • Name
      aas
    • ORF names
      JYM99_04380

Organism names

Accessions

  • Primary accession
    A0A8E5JLA7

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region15-138Acyltransferase
Domain30-140Phospholipid/glycerol acyltransferase
Region233-646AMP-binding

Sequence similarities

In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    719
  • Mass (Da)
    80,493
  • Last updated
    2022-01-19 v1
  • Checksum
    17C60DA3190AE434
MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTSISQQWYMRWLTPLIDFVPLDPTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDGAGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRIQLHILPPTQIPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTKTLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENARGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP074238
EMBL· GenBank· DDBJ
QUZ93853.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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