A0A8E4SEB3 · A0A8E4SEB3_9FLAV
- ProteinGenome polyprotein
- GenePOLY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3392 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1526 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1550 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1610 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2549 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2579 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2580 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2597 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2598 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2624 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2625 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2711 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2930 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2934 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2939 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2942 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3204 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3220 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3339 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus denguei > Dengue virus
Accessions
- Primary accessionA0A8E4SEB3
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 101-119 | Helical | ||||
Sequence: SVTMLLMLMPTALAFHLTT | ||||||
Transmembrane | 724-748 | Helical | ||||
Sequence: YGVLFSGVSWTMKIGIGVLLTWLGL | ||||||
Transmembrane | 754-773 | Helical | ||||
Sequence: SLSMTCIAVGLVTLYLGVMV | ||||||
Transmembrane | 1158-1177 | Helical | ||||
Sequence: MLMTGTLAVFFLLIMGQLTW | ||||||
Transmembrane | 1201-1221 | Helical | ||||
Sequence: YLALMATFKMRPMFAVGLLFR | ||||||
Transmembrane | 1294-1312 | Helical | ||||
Sequence: TMAMILSIVSLFPLCLSTT | ||||||
Transmembrane | 1442-1469 | Helical | ||||
Sequence: ILLKATLLAVSGVYPLSIPATLFVWYFW | ||||||
Transmembrane | 2149-2168 | Helical | ||||
Sequence: LMLLALIAVLTGGVTLFFLS | ||||||
Transmembrane | 2175-2192 | Helical | ||||
Sequence: TSIGLLCVMASSALLWMA | ||||||
Transmembrane | 2198-2215 | Helical | ||||
Sequence: WIAASIILEFFLMVLLIP | ||||||
Transmembrane | 2227-2244 | Helical | ||||
Sequence: QLAYVVIGLLFMILTVAA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 283↔310 | |||||
Sequence: CVGIGSRDFVEGLSGATWVDVVLEHGSC | ||||||
Disulfide bond | 340↔396 | |||||
Sequence: CIEAKISNTTTDSRCPTQGEATLVEEQDANFVCRRTFVDRGWGNGCGLFGKGSLITC | ||||||
Disulfide bond | 354↔385 | |||||
Sequence: CPTQGEATLVEEQDANFVCRRTFVDRGWGNGC | ||||||
Disulfide bond | 372↔401 | |||||
Sequence: CRRTFVDRGWGNGCGLFGKGSLITCAKFKC | ||||||
Disulfide bond | 465↔565 | |||||
Sequence: CSPRTGLDFNEMVLLTMKEKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKC | ||||||
Disulfide bond | 582↔613 | |||||
Sequence: CTGSFKLEKELAETQHGTVLVQIKYEGTDAPC |
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with serine protease NS3.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1346-1475 | Flavivirus NS2B | ||||
Sequence: SWPLNEGIMAVGIVSILLSSLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAEVSWEEEAEHSGASHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAVSGVYPLSIPATLFVWYFWQKKKQR | ||||||
Domain | 1476-1653 | Peptidase S7 | ||||
Sequence: SGVLWDTPSPPEVERAVLDDGIYRIMQRGLLGRSQVGVGVFQENVFHTMWHVTRGAVLMYQGKRLEPSWASVKKDLISYGGGWRLQGSWNTGEEVQVIAVEPGKNPKNVQTAPGTFKTPEGEVGAIALDFKPGTSGSPIVNREGKIVGLYGNGVVTTSGTYVSAIAQAKASQEGPLPE | ||||||
Domain | 1656-1812 | Helicase ATP-binding | ||||
Sequence: DEVFRKRNLTIMDLHPGSGKTRRYLPAIVREAIKRKLRTLILAPTRVVASEMAEALKGMPIRYQTTAVKSEHTGKEIVDLMCHATFTMRLLSPVRVPNYNMIIMDEAHFTDPSSIAARGYISTRVGMGEAAAIFMTATPPGSVEAFPQSNAVIQDEE | ||||||
Domain | 1822-1988 | Helicase C-terminal | ||||
Sequence: SGYEWITDFPGKTVWFVPSIKSGNDIANCLRKNGKRVIQLSRKTFDTEYQKTKNNDWDYVVTTDISEMGANFRADRVIDPRRCLKPVILKDGPERVILAGPMPVTVASAAQRRGRIGRNHNKEGDQYIYMGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPE | ||||||
Domain | 2495-2756 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: TGAQGETLGEKWKRQLNQLSKSEFNTYKRSGIMEVDRSEAKEGLKRGETTKHAVSRGTAKLRWFVERNLVKPEGKVIDLGCGRGGWSYYCAGLKKVTEVKGYTKGGPGHEEPIPMATYGWNLVKLHSGRDVFFIPPEKCDTLLCDIGESSPNPTIEEGRTLRVLKMVEPWLRGNQFCIKILNPYMPSVVETLEQMQRRHGGMLVRNPLSRNSTHEMYWVSCGTGNIVSAVNMTSRMLLNRFTMAHRKPTYERDVDLGAGTRH | ||||||
Domain | 3020-3169 | RdRp catalytic | ||||
Sequence: GNMYADDTAGWDTRITEDDLQNEARITDIMESEHALLAKSIFKLTYQNKVVRVQRPAKNGTVMDVISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMESEGIFSPSELETPNLAERVLDWLEKYGVERLKRMAISGDDCVVKPIDDRFATA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,392
- Mass (Da)379,104
- Last updated2022-01-19 v1
- Checksum29F56D742C6F8B2D