A0A8E1X2W1 · A0A8E1X2W1_LENBU

Function

function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
    EC:3.4.21.92 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

119720406080100120140160180
TypeIDPosition(s)Description
Active site98
Active site98Nucleophile
Active site123

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendopeptidase Clp complex
Molecular FunctionATP-dependent peptidase activity
Molecular FunctionATPase binding
Molecular Functionserine-type endopeptidase activity
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent Clp protease proteolytic subunit
  • EC number
  • Alternative names
    • Endopeptidase Clp

Gene names

    • Name
      clpP
    • ORF names
      FIU77_07740

Organism names

Accessions

  • Primary accession
    A0A8E1X2W1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

Family & Domains

Sequence similarities

Belongs to the peptidase S14 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    21,358
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    E6E3A5C47707F03C2A6BF4102665A478
MNLVPTVIEQSAGGERAYDIYSRLLKDRIIMLSGPIEDDMANAIIAQLLFLDAQDSEKDIYLYINSPGGVITSGMAIYDTMNFVKSDVQTIVMGMAASMASVLASSGAKGKRFALPHAQVLIHQPSGGAQGQQTEIEIAAEEILKARKMINNLLAENSGQPIEKINKDTERDNYLTAQEAVDYGLLDGIMTSSSEKQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VFBT01000015
EMBL· GenBank· DDBJ
MQN22347.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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