A0A8D5U146 · A0A8D5U146_9CREN

Function

function

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site34S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site65spermidine (UniProtKB | ChEBI)
Binding site89spermidine (UniProtKB | ChEBI)
Binding site109S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site141-142S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Active site159Proton acceptor
Binding site168S-methyl-5'-thioadenosine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionspermidine synthase activity
Molecular Functionthermospermine synthase activity
Biological Processspermidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyamine aminopropyltransferase
  • Alternative names
    • Putrescine aminopropyltransferase
      (PAPT
      )
    • Spermidine synthase
      (SPDS
      ; SPDSY
      ) (EC:2.5.1.16
      ) . EC:2.5.1.16 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      speE
    • ORF names
      HS7_06720

Organism names

Accessions

  • Primary accession
    A0A8D5U146

Proteomes

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-240PABS

Sequence similarities

Belongs to the spermidine/spermine synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    302
  • Mass (Da)
    35,025
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    0063CE88F1846E50DED3E56646114F44
MIYRWHWFIEWQTPSEFHAHEIERVYQEQKSKYQEVKLVELTRFGKSLIIDGKIQSTVSDEFIYHESLVHPLMLSLRDPERALIIGGGEGATLREVLRYNSFKEVVMVDIDDVVIEFAKKYMAQWHKGAFEDKRTKLVIEDGIEYLRKNKDEFDVIILDLTDPMKDSPSYKLYTSTFYELVKDSLSHNGGISTQATSPSFSIDSFSVISNTIRHVFGKSEVGVSFVPAFDGLWGFAFYSPNSISPMSQERVDRLLEEKGINGLQYYDGTTHYSMFSIPKYIRKYLENENRISTDDNPIYVPA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024596
EMBL· GenBank· DDBJ
BCU67235.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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