A0A8D5U0W7 · A0A8D5U0W7_9CREN

Function

function

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site56-57NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site64NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site128NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site156-158NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers
Binding site158Fe cation (UniProtKB | ChEBI); ligand shared between two adjacent protomers
Binding site173Fe cation (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site223NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site233glycine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioniron ion binding
Molecular Functionisomerase activity
Molecular Functionpentosyltransferase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process
Biological Processthiazole biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiamine thiazole synthase
  • EC number

Gene names

    • Name
      thi4
    • ORF names
      HS7_05390

Organism names

Accessions

  • Primary accession
    A0A8D5U0W7

Proteomes

Interaction

Subunit

Homooctamer; tetramer of dimers.

Family & Domains

Sequence similarities

Belongs to the THI4 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    261
  • Mass (Da)
    28,139
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    594EC2BD6691DFC4C51EA1573A8BC475
MKQVNEVRISKYIIKETMEDWLDFIDQDVIIVGAGPAGMSAAYYLASAGLKTTIFERRLGFGGGIGGGAMLFHKIIIEEPANQILDEIHVKYKRLEEGIYVVDTAELMAKLASAAIDAGARIINGVSVDDVIFRENPLRVAGVAVEWTATQIANLHVDPIFISAKAVIDATGHDAEIISVASRKLPELNIMIPGEKPAYSEIAEELTVENTGMVAPGLYAAGMAVTEVKALPRMGPIFGSMLMSGKRVAELIISDLQIVKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024596
EMBL· GenBank· DDBJ
BCU67102.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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