A0A8D2FT62 · A0A8D2FT62_THEGE
- ProteinSuccinate-semialdehyde dehydrogenase
- GeneALDH5A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids535 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Catalytic activity
- succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+
Pathway
Amino-acid degradation; 4-aminobutanoate degradation.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 306 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | succinate-semialdehyde dehydrogenase (NAD+) activity | |
Biological Process | gamma-aminobutyric acid catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate-semialdehyde dehydrogenase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Theropithecus
Accessions
- Primary accessionA0A8D2FT62
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 71-530 | Aldehyde dehydrogenase | ||||
Sequence: PAAATFPVQDPASGAVLGMVADCGVSEARAAVRAAYEAFCSWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIYTPAKDKRALVLKQPVGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPPGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGALASKFRNTGQTCVCSNRFLVQRGIHDAFVKAFAEAMKKNLHVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATIVTGGKRHHLGKNFFEPTLLSNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANATDVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length535
- Mass (Da)57,020
- Last updated2022-01-19 v1
- Checksum163D0E7E3E142367
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8D2FUG5 | A0A8D2FUG5_THEGE | ALDH5A1 | 507 |
Keywords
- Technical term