A0A8D2FLY8 · A0A8D2FLY8_THEGE

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for active site, binding site.

150850100150200250300350400450500
Type
IDPosition(s)Description
Active site274Nucleophile
Binding site274Mg2+ (UniProtKB | ChEBI)
Active site276Proton donor
Binding site276Mg2+ (UniProtKB | ChEBI)
Binding site472Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionprotein tyrosine phosphatase activity
Biological Processcell differentiation
Biological Processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Processpositive regulation of DNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Eyes absent homolog
  • EC number

Gene names

    • Name
      EYA2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Theropithecus

Accessions

  • Primary accession
    A0A8D2FLY8

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias209-225Polar residues
Region209-263Disordered
Compositional bias233-262Basic and acidic residues

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. EYA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    508
  • Mass (Da)
    55,608
  • Last updated
    2022-01-19 v1
  • Checksum
    B09F45741B678FF0
MLELVISASLTVNSACLEKLKFHRAGVTVWTLSGREGITRSAPLRVSQLFSRSCPRVLPSQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNAHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGTNLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8D2FJT8A0A8D2FJT8_THEGEEYA2538
A0A8D2FN44A0A8D2FN44_THEGEEYA2459

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias209-225Polar residues
Compositional bias233-262Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help