A0A8D2FLY8 · A0A8D2FLY8_THEGE
- ProteinEyes absent homolog
- GeneEYA2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids508 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 274 | Nucleophile | |||
Binding site | 274 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 276 | Proton donor | |||
Binding site | 276 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 472 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | cell differentiation | |
Biological Process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | |
Biological Process | positive regulation of DNA repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEyes absent homolog
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Theropithecus
Accessions
- Primary accessionA0A8D2FLY8
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 209-225 | Polar residues | |||
Region | 209-263 | Disordered | |||
Compositional bias | 233-262 | Basic and acidic residues | |||
Sequence similarities
Belongs to the HAD-like hydrolase superfamily. EYA family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length508
- Mass (Da)55,608
- Last updated2022-01-19 v1
- ChecksumB09F45741B678FF0
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8D2FJT8 | A0A8D2FJT8_THEGE | EYA2 | 538 | ||
A0A8D2FN44 | A0A8D2FN44_THEGE | EYA2 | 459 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 209-225 | Polar residues | |||
Compositional bias | 233-262 | Basic and acidic residues | |||
Keywords
- Technical term