A0A8D2ET90 · A0A8D2ET90_THEGE
- Proteinhistone acetyltransferase
- GeneEP300
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2334 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- (S)-lactoyl-CoA + L-lysyl-[protein] = CoA + H+ + N6-[(S)-lactoyl]-L-lysyl-[protein]This reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | histone acetyltransferase complex | |
Cellular Component | nucleoplasm | |
Cellular Component | transcription regulator complex | |
Molecular Function | chromatin DNA binding | |
Molecular Function | histone acetyltransferase activity | |
Molecular Function | RNA polymerase II-specific DNA-binding transcription factor binding | |
Molecular Function | transcription coactivator activity | |
Molecular Function | zinc ion binding | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namehistone acetyltransferase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Theropithecus
Accessions
- Primary accessionA0A8D2ET90
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-27 | Disordered | ||||
Sequence: MAENVVEPGPPSAKRPKLSSPALSASA | ||||||
Region | 134-157 | Disordered | ||||
Sequence: PNMGMGTSGPNQGPTQSTGMMNSP | ||||||
Compositional bias | 195-234 | Polar residues | ||||
Sequence: SIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQT | ||||||
Region | 195-235 | Disordered | ||||
Sequence: SIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTG | ||||||
Domain | 331-417 | TAZ-type | ||||
Sequence: DPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPL | ||||||
Zinc finger | 331-417 | TAZ-type | ||||
Sequence: DPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPL | ||||||
Domain | 484-563 | KIX | ||||
Sequence: GIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELE | ||||||
Compositional bias | 672-729 | Polar residues | ||||
Sequence: RMQQPSNQSQFLPQTQFPSQGMNVTNMPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPG | ||||||
Region | 672-968 | Disordered | ||||
Sequence: RMQQPSNQSQFLPQTQFPSQGMNVTNMPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLAPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIPEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMEPTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFK | ||||||
Compositional bias | 745-767 | Pro residues | ||||
Sequence: LHQNSPSPVPSRTPTPHHTPPSI | ||||||
Compositional bias | 775-813 | Pro residues | ||||
Sequence: TTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQ | ||||||
Compositional bias | 814-844 | Polar residues | ||||
Sequence: QVQPSLPAAPSADQPQQQPRSQQSTAASVPT | ||||||
Compositional bias | 857-889 | Polar residues | ||||
Sequence: PLSQPAVSIEGQVSNPPSTSSTEVNSQAIPEKQ | ||||||
Compositional bias | 892-947 | Basic and acidic residues | ||||
Sequence: QEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMEPTETEERSTELKTEIKEEEDQ | ||||||
Domain | 985-1057 | Bromo | ||||
Sequence: RQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVY | ||||||
Domain | 1205-1581 | CBP/p300-type HAT | ||||
Sequence: KFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPTANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQ | ||||||
Compositional bias | 1438-1465 | Basic and acidic residues | ||||
Sequence: LEQEEEERKREENTSNESTDVTKGDSKN | ||||||
Region | 1438-1496 | Disordered | ||||
Sequence: LEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSN | ||||||
Compositional bias | 1466-1483 | Basic residues | ||||
Sequence: AKKKNNKKTSKNKSSLSR | ||||||
Domain | 1583-1631 | ZZ-type | ||||
Sequence: RFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLD | ||||||
Domain | 1646-1727 | TAZ-type | ||||
Sequence: GDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNI | ||||||
Zinc finger | 1646-1727 | TAZ-type | ||||
Sequence: GDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNI | ||||||
Region | 1751-1842 | Disordered | ||||
Sequence: ASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPA | ||||||
Compositional bias | 1769-1804 | Pro residues | ||||
Sequence: TPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPY | ||||||
Compositional bias | 1827-1842 | Pro residues | ||||
Sequence: TPPQTAQPPLPGPPPA | ||||||
Region | 1906-1928 | Disordered | ||||
Sequence: GMQQQPPWGQGGLPQPQQLQSGM | ||||||
Compositional bias | 1908-1928 | Polar residues | ||||
Sequence: QQQPPWGQGGLPQPQQLQSGM | ||||||
Region | 2012-2081 | Disordered | ||||
Sequence: NSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSP | ||||||
Compositional bias | 2018-2032 | Pro residues | ||||
Sequence: IPGQPGMPQGQPGLQ | ||||||
Compositional bias | 2033-2081 | Polar residues | ||||
Sequence: PPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSP | ||||||
Region | 2104-2159 | Disordered | ||||
Sequence: QQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQQQRMQHHMQQMQQGNM | ||||||
Compositional bias | 2124-2159 | Polar residues | ||||
Sequence: ANHNQFQQPQGVGYPPQQQQQQRMQHHMQQMQQGNM | ||||||
Compositional bias | 2186-2230 | Polar residues | ||||
Sequence: QQQMGSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSP | ||||||
Region | 2186-2305 | Disordered | ||||
Sequence: QQQMGSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANL | ||||||
Compositional bias | 2231-2262 | Pro residues | ||||
Sequence: QPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSP | ||||||
Compositional bias | 2282-2305 | Polar residues | ||||
Sequence: GHFASPDQNSMLSQLASNPGMANL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,334
- Mass (Da)255,983
- Last updated2022-01-19 v1
- Checksum104D4D057CDD39F3
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8D2JY50 | A0A8D2JY50_THEGE | EP300 | 2416 | ||
A0A8D2EQX3 | A0A8D2EQX3_THEGE | EP300 | 2390 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 195-234 | Polar residues | ||||
Sequence: SIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQT | ||||||
Compositional bias | 672-729 | Polar residues | ||||
Sequence: RMQQPSNQSQFLPQTQFPSQGMNVTNMPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPG | ||||||
Compositional bias | 745-767 | Pro residues | ||||
Sequence: LHQNSPSPVPSRTPTPHHTPPSI | ||||||
Compositional bias | 775-813 | Pro residues | ||||
Sequence: TTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQ | ||||||
Compositional bias | 814-844 | Polar residues | ||||
Sequence: QVQPSLPAAPSADQPQQQPRSQQSTAASVPT | ||||||
Compositional bias | 857-889 | Polar residues | ||||
Sequence: PLSQPAVSIEGQVSNPPSTSSTEVNSQAIPEKQ | ||||||
Compositional bias | 892-947 | Basic and acidic residues | ||||
Sequence: QEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMEPTETEERSTELKTEIKEEEDQ | ||||||
Compositional bias | 1438-1465 | Basic and acidic residues | ||||
Sequence: LEQEEEERKREENTSNESTDVTKGDSKN | ||||||
Compositional bias | 1466-1483 | Basic residues | ||||
Sequence: AKKKNNKKTSKNKSSLSR | ||||||
Compositional bias | 1769-1804 | Pro residues | ||||
Sequence: TPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPY | ||||||
Compositional bias | 1827-1842 | Pro residues | ||||
Sequence: TPPQTAQPPLPGPPPA | ||||||
Compositional bias | 1908-1928 | Polar residues | ||||
Sequence: QQQPPWGQGGLPQPQQLQSGM | ||||||
Compositional bias | 2018-2032 | Pro residues | ||||
Sequence: IPGQPGMPQGQPGLQ | ||||||
Compositional bias | 2033-2081 | Polar residues | ||||
Sequence: PPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSP | ||||||
Compositional bias | 2124-2159 | Polar residues | ||||
Sequence: ANHNQFQQPQGVGYPPQQQQQQRMQHHMQQMQQGNM | ||||||
Compositional bias | 2186-2230 | Polar residues | ||||
Sequence: QQQMGSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSP | ||||||
Compositional bias | 2231-2262 | Pro residues | ||||
Sequence: QPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSP | ||||||
Compositional bias | 2282-2305 | Polar residues | ||||
Sequence: GHFASPDQNSMLSQLASNPGMANL |
Keywords
- Technical term