A0A8D2EMF6 · A0A8D2EMF6_THEGE

Function

Catalytic activity

  • (R)-3-hydroxybutanoate(out) + 2 Na+(out) = (R)-3-hydroxybutanoate(in) + 2 Na+(in)
  • (S)-lactate(out) + 2 Na+(out) = (S)-lactate(in) + 2 Na+(in)
  • 2 Na+(out) + nicotinate(out) = 2 Na+(in) + nicotinate(in)
  • 2 Na+(out) + propanoate(out) = 2 Na+(in) + propanoate(in)
  • 2 Na+(out) + pyruvate(out) = 2 Na+(in) + pyruvate(in)
  • 4-methyl-2-oxopentanoate(out) + 2 Na+(out) = 4-methyl-2-oxopentanoate(in) + 2 Na+(in)
  • 5-oxo-L-proline(out) + 2 Na+(out) = 5-oxo-L-proline(in) + 2 Na+(in)
  • acetate(out) + 2 Na+(out) = acetate(in) + 2 Na+(in)
  • acetoacetate(out) + 2 Na+(out) = acetoacetate(in) + 2 Na+(in)
  • bromide(in) = bromide(out)
  • butanoate(out) + 2 Na+(out) = butanoate(in) + 2 Na+(in)
  • chloride(in) = chloride(out)
  • iodide(out) = iodide(in)
  • nitrate(in) = nitrate(out)

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Molecular Functiontransmembrane transporter activity
Biological Processsodium ion transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium-coupled monocarboxylate transporter 1
  • Alternative names
    • Electrogenic sodium monocarboxylate cotransporter
    • Solute carrier family 5 member 8

Gene names

    • Name
      SLC5A8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Theropithecus

Accessions

  • Primary accession
    A0A8D2EMF6

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-34Helical
Transmembrane54-72Helical
Transmembrane84-108Helical
Transmembrane129-150Helical
Transmembrane162-182Helical
Transmembrane194-218Helical
Transmembrane240-259Helical
Transmembrane280-302Helical
Transmembrane340-369Helical
Transmembrane390-410Helical
Transmembrane416-436Helical
Transmembrane443-463Helical
Transmembrane521-541Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    66,667
  • Last updated
    2022-01-19 v1
  • Checksum
    1669DB25BD238734
MDMPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAAVIQGGISTILNDAYNGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWSSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYRDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSIFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFATSLWVGIGAQMYPPLPERTSPLQLDIQGCNSTYNETNAMTTTEMPFTTSVFQIHNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLPTGGRKQNLDPRYILTKEDFLSNFDIFKKKKHVLNYKSHPVEDGGTDNPAFNHIELNFSDQSGKSNGTRL

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp